人血小板在体外可有效杀死慢性粒细胞白血病细胞系K-562细胞。
Human platelets effectively kill K-562 cells, a chronic myelogenic leukemia cell line, in vitro.
作者信息
Sagawa T, Kodama T, Tominaga A, Okada M
机构信息
Department of Clinical Pathology, Ehime College of Health Science.
出版信息
Jpn J Cancer Res. 1990 May;81(5):449-53. doi: 10.1111/j.1349-7006.1990.tb02590.x.
Abstract
The cytotoxic effect of isolated human platelets on leukemic cells has been examined in order to investigate the role of platelets in host defense systems. K-562 cells (a chronic myelogenic leukemia cell line) showed significant change in their morphology and were killed when they were incubated with platelets in serum-free medium for several hours at 37 degrees C, a condition where no killing of normal peripheral lymphocytes occurred. Some protease inhibitors inhibited the cytotoxicity of platelets against K-562 cells. Our results suggest that platelets may be involved in host defense against neoplasia and that certain proteases are implicated in the cytotoxic effect of platelets.
摘要
为了研究血小板在宿主防御系统中的作用，对分离出的人血小板对白血病细胞的细胞毒性作用进行了检测。K-562细胞（一种慢性粒细胞白血病细胞系）在无血清培养基中于37℃与血小板孵育数小时后，其形态出现显著变化并被杀死，而在这种条件下正常外周淋巴细胞未被杀死。一些蛋白酶抑制剂可抑制血小板对K-562细胞的细胞毒性。我们的结果表明，血小板可能参与宿主对肿瘤的防御，并且某些蛋白酶与血小板的细胞毒性作用有关。
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