微出血与脑小血管病老年患者的步态障碍独立相关。
Microbleeds are independently related to gait disturbances in elderly individuals with cerebral small vessel disease.
机构信息
Department of Neurology, Radboud University, Nijmegen Medical Centre, 6500 HB Nijmegen, the Netherlands.
出版信息
Stroke. 2011 Feb;42(2):494-7. doi: 10.1161/STROKEAHA.110.596122. Epub 2010 Dec 16.
BACKGROUND AND PURPOSE
Cerebral small vessel disease (SVD), including white matter lesions and lacunar infarcts, is related to gait disturbances. Microbleeds (MB) are another manifestation of SVD, but their clinical impact remains unclear. We therefore investigated the relation between the number and location of MB and gait, independently of white matter lesions and lacunar infarcts.
METHODS
MRI scanning was performed in 485 nondemented elderly individuals with cerebral SVD. The number and location of MB were rated. Gait was assessed with a GAITRite system and the Tinetti and Timed-Up-and-Go tests. MB were related to gait parameters by age, height, total brain volume, white matter lesions, and number of lacunar infarcts-adjusted linear regression.
RESULTS
A higher number of MB was independently related to a shorter stride length and poorer performance on the Tinetti and Timed-Up-and-Go tests. These relations seemed to be explained by MB in the temporal and frontal lobe and basal ganglia, including the thalamus.
CONCLUSIONS
This study offers the first indication that MB may be associated with gait disturbances, independently of other coexisting markers of SVD.
背景与目的
脑小血管病（SVD）包括白质病变和腔隙性梗死，与步态障碍有关。微出血（MB）是 SVD 的另一种表现形式，但它们的临床影响尚不清楚。因此，我们研究了 MB 的数量和位置与步态之间的关系，独立于白质病变和腔隙性梗死。
方法
对 485 例无痴呆的脑 SVD 老年患者进行 MRI 扫描。对 MB 的数量和位置进行评分。使用 GAITRite 系统和 Tinetti 和 Timed-Up-and-Go 测试评估步态。通过年龄、身高、总脑体积、白质病变和腔隙性梗死数量调整线性回归，将 MB 与步态参数相关联。
结果
MB 的数量与步幅较短和 Tinetti 和 Timed-Up-and-Go 测试表现较差独立相关。这些关系似乎可以通过颞叶和额叶以及基底节区（包括丘脑）的 MB 来解释。
结论
这项研究首次表明，MB 可能与步态障碍有关，独立于其他共存的 SVD 标志物。
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