Tian Fenghua, Delgado Mauricio R, Dhamne Sameer C, Khan Bilal, Alexandrakis George, Romero Mario I, Smith Linsley, Reid Dahlia, Clegg Nancy J, Liu Hanli
Department of Bioengineering, University of Texas at Arlington, Joint Graduate Program in Biomedical Engineering between University of Texas at Arlington and University of Texas Southwestern Medical Center at Dallas, 501 West First Street, Arlington, TX 76019, USA.
Opt Express. 2010 Dec 6;18(25):25973-86. doi: 10.1364/OE.18.025973.
Cerebral palsy (CP) is the most common motor disorder in children. Currently available neuroimaging techniques require complete body confinement and steadiness and thus are extremely difficult for pediatric patients. Here, we report the use and quantification of functional near infrared spectroscopy (fNIRS) to investigate the functional reorganization of the sensorimotor cortex in children with hemiparetic CP. Ten of sixteen children with congenital hemiparesis were measured during finger tapping tasks and compared with eight of sixteen age-matched healthy children, with an overall measurement success rate of 60%. Spatiotemporal analysis was introduced to quantify the motor activation and brain laterality. Such a quantitative approach reveals a consistent, contralateral motor activation in healthy children at 7 years of age or older. In sharp contrast, children with congenital hemiparesis exhibit all three of contralateral, bilateral and ipsilateral motor activations, depending on specific ages of the pediatric subjects. This study clearly demonstrates the feasibility of fNIRS to be utilized for investigating cortical reorganization in children with CP or other cortical disorders.
脑瘫（CP）是儿童中最常见的运动障碍。目前可用的神经成像技术需要患者全身保持静止，这对于儿科患者来说极其困难。在此，我们报告了使用功能近红外光谱（fNIRS）并对其进行量化，以研究偏瘫型脑瘫患儿感觉运动皮层的功能重组。在16名先天性偏瘫儿童中，有10名在进行手指敲击任务时接受了测量，并与16名年龄匹配的健康儿童中的8名进行了比较，总体测量成功率为60%。引入了时空分析来量化运动激活和脑侧化。这种定量方法揭示了7岁及以上健康儿童中一致的对侧运动激活。与之形成鲜明对比的是，先天性偏瘫儿童根据其具体年龄表现出对侧、双侧和同侧运动激活这三种情况。这项研究清楚地证明了fNIRS用于研究脑瘫患儿或其他皮层疾病患儿皮层重组的可行性。
