Harvey S, Lea R W, Ahene C
Department of Physiology, University of Alberta, Edmonton, Canada.
J Endocrinol. 1990 Jul;126(1):83-8. doi: 10.1677/joe.0.1260083.
Peripheral plasma concentrations of GH in adult chickens were increased, in a dose-related manner, between 5 and 30 min after the intracerebroventricular (i.c.v.) injection of 0.1 or 10 micrograms TRH. In contrast, i.v. administration of comparable doses of TRH had no significant effect on circulating GH concentrations. [3H]3-methyl-histidine2-TRH [( 3H]Me-TRH) was located in the pituitary gland and peripheral plasma within 5 min of its i.c.v. administration, although in amounts that were unlikely to affect directly pituitary function. [3H]Me-TRH rapidly accumulated in the hypothalamus following its i.c.v. administration (but not after i.v. injection), and the central effect of TRH on GH secretion in birds is therefore likely to be induced by effects at hypothalamic sites.
成年鸡脑室内注射0.1或10微克促甲状腺激素释放激素（TRH）后5至30分钟内，外周血浆中生长激素（GH）的浓度呈剂量依赖性增加。相比之下，静脉注射同等剂量的TRH对循环中GH浓度没有显著影响。[3H]3-甲基组氨酸2-TRH（[3H]Me-TRH）脑室内给药后5分钟内可在垂体和外周血浆中检测到，但其量不太可能直接影响垂体功能。[3H]Me-TRH脑室内给药后（静脉注射后则不会）迅速在下丘脑蓄积，因此TRH对鸟类GH分泌的中枢作用可能是由下丘脑部位的作用所诱导的。
