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白细胞介素-12 信号调节的 CD43 表达与 CD8 T 细胞存活相关。

CD43 Expression Regulated by IL-12 Signaling Is Associated with Survival of CD8 T Cells.

机构信息

Division of Life and Pharmaceutical Sciences, and Center for Cell Signaling & Drug Discovery Research, Ewha Womans University, Seoul 120-750, Korea.

出版信息

Immune Netw. 2010 Oct;10(5):153-63. doi: 10.4110/in.2010.10.5.153. Epub 2010 Oct 31.

DOI:10.4110/in.2010.10.5.153
PMID:21165244
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2993947/
Abstract

BACKGROUND

In addition to TCR and costimulatory signals, cytokine signals are required for the differentiation of activated CD8 T cells into memory T cells and their survival. Previously, we have shown that IL-12 priming during initial antigenic stimulation significantly enhanced the survival of activated CD8 T cells and increased the memory cell population. In the present study, we analyzed the mechanisms by which IL-12 priming contributes to activation and survival of CD8 T cells.

METHODS

We observed dramatically decreased expression of CD43 in activated CD8 T cells by IL-12 priming. We purified CD43(lo) and CD43(hi) cells after IL-12 priming and analyzed the function and survival of each population both in vivo and in vitro.

RESULTS

Compared to CD43(hi) effector cells, CD43(lo) effector CD8 T cells exhibited reduced cytolytic activity and lower granzyme B expression but showed increased survival. CD43(lo) effector CD8 T cells also showed increased in vivo expansion after adoptive transfer and antigen challenge. The enhanced survival of CD43(lo) CD8 T cells was also partly associated with CD62L expression.

CONCLUSION

We suggest that CD43 expression regulated by IL-12 priming plays an important role in differentiation and survival of CD8 T cells.

摘要

背景

除了 TCR 和共刺激信号外，细胞因子信号对于激活的 CD8 T 细胞分化为记忆 T 细胞及其存活也是必需的。先前，我们已经表明，在初始抗原刺激期间的 IL-12 引发显著增强了激活的 CD8 T 细胞的存活，并增加了记忆细胞群体。在本研究中，我们分析了 IL-12 引发有助于 CD8 T 细胞激活和存活的机制。

方法

我们观察到 IL-12 引发导致激活的 CD8 T 细胞中 CD43 的表达显著降低。我们在 IL-12 引发后纯化 CD43(lo)和 CD43(hi)细胞，并在体内和体外分析每个群体的功能和存活。

结果

与 CD43(hi)效应细胞相比，CD43(lo)效应 CD8 T 细胞表现出降低的细胞毒性活性和较低的颗粒酶 B 表达，但表现出增加的存活。CD43(lo)效应 CD8 T 细胞在过继转移和抗原挑战后也显示出体内扩增的增加。CD43(lo)CD8 T 细胞的增强存活也部分与 CD62L 表达有关。

结论

我们认为，IL-12 引发调节的 CD43 表达在 CD8 T 细胞的分化和存活中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/458ed3f33031/in-10-153-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/cbe8a27c003b/in-10-153-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/a258e29d4e23/in-10-153-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/f24302afbbab/in-10-153-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/0e94dc143c79/in-10-153-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/b0c3e6bfefbd/in-10-153-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/458ed3f33031/in-10-153-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/cbe8a27c003b/in-10-153-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/a258e29d4e23/in-10-153-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/f24302afbbab/in-10-153-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/0e94dc143c79/in-10-153-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/b0c3e6bfefbd/in-10-153-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d73/2993947/458ed3f33031/in-10-153-g006.jpg

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