Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea.
J Korean Med Sci. 2010 Dec;25(12):1727-32. doi: 10.3346/jkms.2010.25.12.1727. Epub 2010 Nov 24.
This study was conducted to evaluate the immunogenicity and safety of diphtheria-tetanus (Td) vaccine in adults over 40 yr old who had never received a diphtheria-tetanus-pertussis (DTP) vaccination. A total of 242 subject completed three-doses of Td vaccination and subsequent assays for immunogenicity. Before vaccination, 33.9% and 96.7% participants showed antibody levels of diphtheria and tetanus, respectively, which were below protective level (<0.1 U/mL). After the first dose of Td vaccine, 92.6% and 77.6% of subjects gained protective antibody concentrations (≥ 0.1 U/mL) for diphtheria and tetanus, with an increase to 99.6% and 100% after the third dose. Local and systemic adverse events occurred in 37.9% and 15.5% of the subjects. No serious adverse event requiring an unscheduled hospital visit occurred. In conclusion, three-doses of Td vaccination to unimmunized adults are safe and effective in inducing protective immunity against diphtheria and tetanus.
本研究旨在评估从未接受过白喉-破伤风-百日咳（DTP）疫苗接种的 40 岁以上成年人接种白喉-破伤风（Td）疫苗的免疫原性和安全性。共有 242 名受试者完成了三剂 Td 疫苗接种和随后的免疫原性检测。接种前，分别有 33.9%和 96.7%的参与者的白喉和破伤风抗体水平低于保护水平（<0.1 U/mL）。接种 Td 疫苗第一剂后，92.6%和 77.6%的受试者获得了白喉和破伤风的保护性抗体浓度（≥0.1 U/mL），第三剂后分别增加至 99.6%和 100%。37.9%和 15.5%的受试者出现局部和全身不良反应。未发生需要非计划性住院治疗的严重不良事件。总之，未免疫成年人接种三剂 Td 疫苗安全有效，可诱导对白喉和破伤风的保护性免疫。
