Department of Pharmacology, Division of Molecular and Cellular Biology, Kashihara, Nara University 634-8521, Japan.
Korean J Physiol Pharmacol. 2010 Oct;14(5):249-56. doi: 10.4196/kjpp.2010.14.5.249. Epub 2010 Oct 31.
Gender differences in the trace elements of monkey sino-atrial (SA) node were investigated in a process of age-dependent alterations. Sixty hearts from Japanese and rhesus monkeys (30 male and 30 female) used were aged ranging from 1-day- to 30-year-old. The elements were analyzed using an inductively coupled plasma-atomic emission spectrometer (ICP-AES). Advancing age decreased all the trace elements. Ca, P, S and Mg significantly decreased. The correlation coefficients of Ca and P were -0.178±0.081 (p<0.05) and -0.088±0.022 (p<0.05) in male (n=30), and -0.095±0.026 (p<0.05) and -0.069±0.017 (p<0.05) in female (n=30), respectively. The age-dependent coefficients for Fe/Ca, Zn/Ca, Fe/P, Fe/S, Zn/S, Fe/Mg and Zn/Mg were exhibited markedly in male, but all was less in female. In gender-related differences, only a ratio of P/Ca (p<0.05) was significantly observed with ageing. The trace elements such as Cu, Se and Sn were less detected in the SA nodes. These results indicate that the age-dependent changes in the ratios of elements are appeared more rapidly in male monkey SA node, and the gender difference is observed in ratio of P/Ca. The different attenuations may be involved with the age- and gender-related SA nodal functions.
探讨了猴窦房结（SA）结中微量元素在年龄依赖性变化过程中的性别差异。使用了 60 颗来自日本和恒河猴的心脏（30 只雄性和 30 只雌性），年龄从 1 天到 30 岁不等。使用电感耦合等离子体原子发射光谱仪（ICP-AES）分析元素。随着年龄的增长，所有微量元素都减少了。Ca、P、S 和 Mg 显著减少。在雄性（n=30）中，Ca 和 P 的相关系数分别为-0.178±0.081（p<0.05）和-0.088±0.022（p<0.05），在雌性（n=30）中，Ca 和 P 的相关系数分别为-0.095±0.026（p<0.05）和-0.069±0.017（p<0.05）。Fe/Ca、Zn/Ca、Fe/P、Fe/S、Zn/S、Fe/Mg 和 Zn/Mg 的年龄依赖性系数在雄性中表现出明显的差异，但在雌性中则较少。在性别相关差异中，只有 P/Ca 比值（p<0.05）随年龄增长而显著观察到。在 SA 节点中较少检测到 Cu、Se 和 Sn 等微量元素。这些结果表明，雄性猴 SA 节点中元素比值的年龄依赖性变化出现得更快，并且观察到 P/Ca 比值的性别差异。不同的衰减可能与年龄和性别相关的 SA 节点功能有关。
