Department of Biology Science, Fuyang Normal College, Qing He East Road No. 741, Fuyang, China.
Biochem Genet. 2011 Apr;49(3-4):226-41. doi: 10.1007/s10528-010-9401-9. Epub 2010 Dec 17.
The zebra finch (Taeniopygia guttata) is an established organism for developmental, behavioral, and neurological research. In this study, we conducted a genomewide survey using the zebra finch genome project databases and identified 86 bHLH sequences in silico in the zebra finch genome. Phylogenetic analysis revealed that 85 proteins belong to 38 families with 29, 18, 18, 3, 11, and 6 bHLH members in supergroups A, B, C, D, E, and F, respectively. One orphan member belonged to none of these groups. Comparisons of zebra finch with chicken and human bHLH repertoires suggested that both humans and birds have a number of lineage-specific bHLH members. Chromosome distribution patterns and phylogenetic analysis suggest that the zebra finch bHLH members should have arisen through gene duplication. This study provides useful information for further research using zebra finch as a model system.
虎皮鹦鹉（Taeniopygia guttata）是一种成熟的发育、行为和神经科学研究模型生物。在这项研究中，我们利用虎皮鹦鹉基因组计划数据库进行了全基因组调查，在虎皮鹦鹉基因组中鉴定出了 86 个 bHLH 序列。系统发育分析表明，85 个蛋白质属于 38 个家族，超家族 A、B、C、D、E 和 F 分别包含 29、18、18、3、11 和 6 个 bHLH 成员。一个孤儿成员不属于这些家族中的任何一个。与鸡和人 bHLH 基因库的比较表明，人类和鸟类都有许多谱系特异性的 bHLH 成员。染色体分布模式和系统发育分析表明，虎皮鹦鹉 bHLH 成员可能是通过基因复制产生的。这项研究为利用虎皮鹦鹉作为模型系统进行进一步研究提供了有用的信息。
