Wang Yongbo, Shi Anna, Shi Xun, Liu Weifeng
Department of Ophthalmology, The Third Affiliated Hospital of Nanchang University, Nanchang.
Yan Ke Xue Bao. 2010 Aug;25(1):22-5. doi: 10.3969/g.issn.1000-4432.2010.01.006.
To evaluate the effect of intravitreal injection of triamcinolone acetonide(IVTA) combining with retinal laser treating for diabetic macular edema(DME).
Twenty five patients(32 eyes) with DME who has microangioma in macula lutea were randomly divided into group A, B,C and D(8 eyes each group). Eyes in group A were treated with laser photocoagulation. Eyes in group B were treated with multiplier-532 laser photocoagulation and transpupillary thermotherapy. Eyes in group C were treated with multiplier-532 laser photocoagulation and intravitreal triamcinolone acetonide. Eyes in group D were treated with multiplier-532 laser, transpupillary thermotherapy plus triamcinolone acetonide injection. Intravitreal injection of 4 mg triamcinolone acetonide was done 1 week after laser photocoagulation in group C and D. The visual acuity, intraocular pressure, macular thickness (foveal thickness) of the eyes in 4 groups were observed before and 1, 3 and 6 months after treatment.
The visual acuity, intraocular pressure and foveal thickness of the 4 groups before treatment showed no significant difference(p> ). The visual acuity, intraocular pressure, macular thickness of eyes in group A, B were better than those of group C, D at 1, 3 and 6 months after treatment, and they had significant difference(p<0.05), while they didn't show significant difference between group A and B, group C and D(p>0.05).
The effect of laser photocoagulation and intravitreal triamcinolone acetonide, laser photocoagulation combining with transpupillary thermotherapy plus triamcinolone acetonide injectionvisual treating for DME was better than laser photocoagulation alone, laser photocoagulation combining with transpupillary thermotherapy.
评估玻璃体腔内注射曲安奈德（IVTA）联合视网膜激光治疗糖尿病性黄斑水肿（DME）的效果。
将25例（32只眼）黄斑区有微血管瘤的DME患者随机分为A、B、C、D组（每组8只眼）。A组眼行激光光凝治疗。B组眼行倍频532激光光凝联合经瞳孔温热疗法。C组眼行倍频532激光光凝联合玻璃体腔内注射曲安奈德。D组眼行倍频532激光、经瞳孔温热疗法联合曲安奈德注射。C组和D组在激光光凝治疗1周后行玻璃体腔内注射4mg曲安奈德。观察4组眼治疗前及治疗后1、3、6个月时的视力、眼压、黄斑厚度（中心凹厚度）。
4组治疗前的视力、眼压及中心凹厚度差异无统计学意义（p> ）。治疗后1、3、6个月时，A、B组眼的视力、眼压、黄斑厚度均优于C、D组，差异有统计学意义（p<0.05），而A组与B组、C组与D组之间差异无统计学意义（p>0.05）。
激光光凝联合玻璃体腔内注射曲安奈德、激光光凝联合经瞳孔温热疗法加曲安奈德注射治疗DME的效果优于单纯激光光凝、激光光凝联合经瞳孔温热疗法。
