Department of Chemistry, University of Alberta, Edmonton, Alberta, T6G 2G2, Canada.
Langmuir. 2011 Jan 18;27(2):741-50. doi: 10.1021/la1041647. Epub 2010 Dec 17.
We report the synthesis and self-assembly of azide and amine trimethoxysilanes that result in mixed monolayers on silica. The amine and azide functional groups can be independently reacted with acid chlorides and terminal alkynes, respectively. Consequently, these orthogonally reactive monolayers represent a general starting point for making bifunctional surfaces. Using X-ray photoelectron spectroscopy, we determined the azide/amine surface ratio as well as the reactivity of the azide and amine functional groups in the mixed self-assembled monolayer (SAM). Significantly, the surface azide/amine ratio was much lower than the azide/amine ratio in the self-assembly mixture. After determining the self-assembly mixture composition that would afford 1:1 azide-amine mixed monolayers, we demonstrated their subsequent functionalization. The resulting bifunctional surface has a similar functional group ratio to the azide/amine precursor SAM demonstrating the generality of this approach.
我们报告了叠氮化物和胺三甲氧基硅烷的合成和自组装，这些化合物在二氧化硅上形成混合单层。胺和叠氮基官能团可以分别与酰氯和末端炔烃反应。因此，这些正交反应性单层代表了制备双官能表面的通用起点。使用 X 射线光电子能谱，我们确定了混合自组装单层（SAM）中的叠氮化物/胺表面比以及叠氮化物和胺官能团的反应性。重要的是，表面叠氮化物/胺的比例远低于自组装混合物中的比例。在确定了可提供 1:1 叠氮化物-胺混合单层的自组装混合物组成后，我们证明了它们的后续功能化。所得的双官能表面具有与叠氮化物/胺前体 SAM 相似的官能团比例，证明了这种方法的通用性。
