Dorr R T
Arizona Cancer Center, University of Arizona College of Medicine, Tucson.
Semin Oncol. 1990 Aug;17(4 Suppl 7):2-5.
Observations have been made of the multiple-drug resistance phenomenon in mitomycin-exposed cells in vitro. Collateral resistance to anthracyclines and Vinca alkaloids was demonstrated in mitomycin carbon-treated 1-1210 cells in vitro. However, because it has also been found that this resistance can be reversed with agents such as verapamil and progestogens, it may be possible to effect a similar reversal in vivo. A study is currently being performed in patients with colorectal cancer, in which the potential for reversal is being tested. The pharmacokinetics of ifosfamide result in high cytotoxic specificity which, along with its therapeutic range, makes it a particularly active agent in the treatment of non-small cell lung cancer. Its urotoxicity is effectively controlled by the coadministration of mesna, a uroprotective agent.
已对体外丝裂霉素处理的细胞中的多药耐药现象进行了观察。体外实验表明，丝裂霉素C处理的1-1210细胞对蒽环类药物和长春花生物碱存在交叉耐药性。然而，由于还发现这种耐药性可用维拉帕米和孕激素等药物逆转，因此有可能在体内实现类似的逆转。目前正在对结直肠癌患者进行一项研究，以测试逆转的可能性。异环磷酰胺的药代动力学导致其具有高细胞毒性特异性，连同其治疗范围，使其成为治疗非小细胞肺癌的一种特别有效的药物。其尿路毒性可通过同时给予尿路保护剂美司钠有效控制。
