Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 Stadium Mall Drive, West Lafayette, IN 47907, USA.
Int J Pharm. 2011 Sep 30;417(1-2):3-16. doi: 10.1016/j.ijpharm.2010.12.011. Epub 2010 Dec 15.
In this article, the use of mid-IR in pharmaceutical settings is reviewed. An overview of mid-IR instrumentation and sampling techniques is provided. Subsequently, different pharmaceutical applications of the technique are described, including structure elucidation and identification, characterization of crystalline (polymorphs, hydrates, salts and co-crystals) and amorphous forms, as well as quantitative and remote sensing applications. Finally, an overview of current trends in FTIR-based imaging applications is provided, with special attention paid to currently emerging FTIR-AFM coupled techniques which have high spatial resolution.
本文综述了中红外（mid-IR）在制药领域的应用。概述了中红外仪器和采样技术。随后，描述了该技术在不同制药领域的应用，包括结构解析和鉴定、结晶（多晶型物、水合物、盐和共晶）和无定形形式的特性，以及定量和遥感应用。最后，概述了基于傅里叶变换红外（FTIR）的成像应用的当前趋势，特别关注具有高空间分辨率的新兴 FTIR-AFM 耦合技术。
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