Department of Neurology, Inje University Ilsan-Paik Hospital, Goyang, Republic of Korea.
J Neurol Sci. 2011 Feb 15;301(1-2):12-3. doi: 10.1016/j.jns.2010.11.017. Epub 2010 Dec 16.
The pathomechanism of amyotrophic lateral sclerosis (ALS) with parkinsonism (ALS-P) has not been clarified. We report two patients with ALS-P who showed dysfunction of the nigrostriatal system. The first patient showed tremor dominant, asymmetric parkinsonism which was more severe on the right side, while the second patient exhibited predominant freezing of gait. Both patients showed reduced uptake of [¹⁸F] N-(3-fluoropropyl)-2ß-carbon ethoxy-3ß-(4-iodophenyl) nortropane (¹⁸F-FP-CIT) in the posterior parts of bilateral putamina on positron emission tomography (PET). Based on our PET findings, we suggest that presynaptic nigrostriatal dysfunction may be involved in the pathomechanism of parkinsonism combined with ALS.
肌萎缩侧索硬化伴帕金森病（ALS-P）的发病机制尚未阐明。我们报告了 2 例表现为黑质纹状体系统功能障碍的 ALS-P 患者。第 1 例患者表现为震颤为主、不对称性帕金森病，右侧更严重，第 2 例患者表现为步态冻结为主。这两例患者的正电子发射断层扫描（PET）均显示双侧豆状核后部[¹⁸F] N-（3-氟丙基）-2β-碳乙氧基-3β-（4-碘苯基）-nortropane（¹⁸F-FP-CIT）摄取减少。根据我们的 PET 结果，我们认为，突触前黑质纹状体功能障碍可能参与了伴有 ALS 的帕金森病的发病机制。
Zotero 插件