皮肤中的上皮-间充质转化。
Epithelial-mesenchymal transition in the skin.
机构信息
Department of Dermatology, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
出版信息
J Dermatol Sci. 2011 Jan;61(1):7-13. doi: 10.1016/j.jdermsci.2010.11.015. Epub 2010 Dec 5.
Abstract
Epithelial-mesenchymal transition (EMT) plays important roles not only in the morphogenesis but also in wound repair, tissue fibrosis and cancer progression. Recently, regulatory mechanism of this process has been elaborately elucidated. EMT can be a new therapeutic target for treating skin ulcer, fibrosing alopecia, and malignant cutaneous cancers, including squamous cell carcinoma and melanoma.
摘要
上皮-间充质转化（EMT）不仅在形态发生中发挥重要作用，而且在伤口修复、组织纤维化和癌症进展中也发挥重要作用。最近，这一过程的调控机制已经被详细阐明。EMT 可能成为治疗皮肤溃疡、纤维性脱发和恶性皮肤癌（包括鳞状细胞癌和黑色素瘤）的新治疗靶点。
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