Department of Medical Microbiology, Medical University of Silesia, Katowice, Poland.
Anaerobe. 2011 Feb;17(1):43-5. doi: 10.1016/j.anaerobe.2010.12.003. Epub 2010 Dec 16.
Stools from autistic and healthy children were studied for fecal lactoferrin, Clostridium difficile toxins, Clostridium perfringens enterotoxin and cultured for Clostridium spp. Elevated level of FLA was demonstrated in 24.4% stools, all from boys (31.25%). No toxins were detected. Clostridium spp. was isolated with similar frequency from all samples. C. perfringens were isolated significantly often from the autistic stools, intermediate sensitive strains to penicillin 19%, to clindamycin 11.3%, and to metronidazole 7.5% were detected. Further studies on fecal microflora and inflammatory mediators, with larger groups of patients, are required in order to explain their role in neurological deficits.
对自闭症儿童和健康儿童的粪便进行了研究，检测了粪便乳铁蛋白、艰难梭菌毒素、产气荚膜梭菌肠毒素，并培养了梭状芽孢杆菌。在 24.4%的粪便中（全部来自男孩，占 31.25%）检测到 FLA 水平升高。未检测到毒素。从所有样本中分离出的梭状芽孢杆菌具有相似的频率。从自闭症儿童的粪便中分离出的产气荚膜梭菌显著增多，对青霉素的中间敏感菌株为 19%，克林霉素为 11.3%，甲硝唑为 7.5%。需要进一步研究粪便微生物群和炎症介质，以更大的患者群体为对象，以便解释它们在神经功能缺损中的作用。
