美司钠的核磁共振谱与分子结构
Nuclear magnetic resonance spectra and molecular structure of mesna.
作者信息
Hägele G, Batz M, Peters R, Niemeyer U, Engel J
机构信息
Institut für Anorganische Chemie und Strukturchemie, Heinrich-Heine-Universität Düsseldorf, Fed. Rep. of Germany.
出版信息
Arzneimittelforschung. 1990 May;40(5):599-602.
PMID:2116804
Abstract
Mesna (2-mercapto-ethane sulfonic acid sodium salt) is used as a reliably acting uroprotector in cancer chemotherapy with oxazaphosphorine cytostatics. 1H-, 13C[1H]- and C,H-COSY-NMR-spectra are analyzed. In solution state mesna exists predominantly in a trans-rotameric form. These findings are supported by hypothetical gas-phase-structures of mesna, simulated via the program system MOPAC.
摘要
美司钠（2-巯基乙烷磺酸钠盐）在使用氮杂磷三环类细胞抑制剂进行癌症化疗时用作可靠的尿路保护剂。对1H-、13C[1H]-和C,H-COSY-NMR光谱进行了分析。在溶液状态下，美司钠主要以反式旋转异构体形式存在。这些发现得到了通过程序系统MOPAC模拟的美司钠假设气相结构的支持。
Zotero 插件