Research Resources Center, RIKEN Brain Science Institute, Hirosawa 2-1, Wako, Saitama, 351-0198, Japan.
Behav Brain Res. 2011 Apr 15;218(2):353-6. doi: 10.1016/j.bbr.2010.12.019. Epub 2010 Dec 17.
Heterozygous rolling Nagoya (rol/+) mice with a Ca(V)2.1α₁ mutation show normal Y-maze behavior. Intra-accumbens injection of N-methyl-d-aspartate (NMDA; 0-2.0 μg/side) induced similar spontaneous alternations in wild-type and rol/+ mice; injections of NMDA receptor antagonist MK-801 (0.5 μg/side) or Ca(V)2.1 inhibitor levetiracetam (0.1 μg/side) did not affect controls but decreased spatial cognition in rol/+ mice, suggesting that Ca(V)2.1-mediated NMDA receptor signaling in the nucleus accumbens is involved in short-term spatial learning.
杂合型滚动名古屋（rol/+）突变小鼠 Ca(V)2.1α₁ 显示正常 Y 迷宫行为。纹状体核内注射 N-甲基-D-天冬氨酸（NMDA；0-2.0μg/侧）诱导野生型和 rol/+ 小鼠相似的自发交替；NMDA 受体拮抗剂 MK-801（0.5μg/侧）或 Ca(V)2.1 抑制剂左乙拉西坦（0.1μg/侧）的注射不会影响对照，但减少 rol/+ 小鼠的空间认知，表明核内纹状体的 Ca(V)2.1 介导的 NMDA 受体信号参与短期空间学习。
