精氨酸和瓜氨酸的完整微观种分析。
The complete microspeciation of arginine and citrulline.
机构信息
Department of Pharmaceutical Chemistry, Semmelweis University, Research Group of Drugs of Abuse and Doping Agents, Hungarian Academy of Sciences, Budapest H-1092, Hőgyes Endre utca 9, Hungary.
出版信息
J Pharm Biomed Anal. 2011 Apr 5;54(5):965-71. doi: 10.1016/j.jpba.2010.11.023. Epub 2010 Nov 25.
(1)H NMR-pH titrations of arginine, the most basic natural amino acid and citrulline, its neutral counterpart were carried out. Two other closely related auxiliary compounds were also studied. The 8 macroscopic protonation constants were determined. Combining the four datasets in a deductive method, all the 12 microconstants of arginine, the 4 microconstants of citrulline and arginine amide were calculated. An error-propagation analysis and the pH-dependent distribution of the 8 arginine microspecies are provided.
（1）进行了精氨酸（最基本的天然氨基酸）和瓜氨酸（其中性对应物）的 1H NMR-pH 滴定。还研究了另外两种密切相关的辅助化合物。确定了 8 个宏观质子化常数。通过演绎法将这四个数据集结合起来，计算出了精氨酸的 12 个微常数、瓜氨酸的 4 个微常数和精氨酸酰胺的 4 个微常数。提供了误差传播分析和 8 种精氨酸微观种的 pH 依赖性分布。
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