细丝蛋白：细胞结构与功能的组织者。
The filamins: organizers of cell structure and function.
机构信息
Translational Medicine Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
出版信息
Cell Adh Migr. 2011 Mar-Apr;5(2):160-9. doi: 10.4161/cam.5.2.14401. Epub 2011 Mar 1.
Abstract
Filamin A (FLNa), the first non-muscle actin filament cross-linking protein, was identified in 1975. Thirty five years of FLNa research has revealed its structure in great detail, discovered its isoforms (FLNb and c), and identified over 90 binding partners including channels, receptors, intracellular signaling molecules, and even transcription factors. Due to this diversity, mutations in human FLN genes result in a wide range of anomalies with moderate to lethal consequences. This review focuses on the structure and functions of FLNa in cell migration and adhesion.
摘要
细丝蛋白 A（FLNa）是 1975 年发现的第一个非肌肉肌动蛋白丝交联蛋白。35 年来，FLNa 的研究已经详细揭示了其结构，发现了其同工型（FLNb 和 c），并鉴定了 90 多个结合伙伴，包括通道、受体、细胞内信号分子，甚至转录因子。由于这种多样性，人类 FLN 基因突变导致广泛的异常，从中度到致命的后果。本综述重点介绍 FLNa 在细胞迁移和黏附中的结构和功能。
相似文献
1
The filamins: organizers of cell structure and function.细丝蛋白：细胞结构与功能的组织者。
Cell Adh Migr. 2011 Mar-Apr;5(2):160-9. doi: 10.4161/cam.5.2.14401. Epub 2011 Mar 1.
2
Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions.细丝蛋白耗竭阻止内质网扩展并破坏力承载黏附。
Mol Biol Cell. 2011 Apr 15;22(8):1263-73. doi: 10.1091/mbc.E10-08-0661. Epub 2011 Feb 16.
3
Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells.细丝蛋白 A 控制基质金属蛋白酶活性并调节人纤维肉瘤细胞的细胞侵袭。
J Cell Sci. 2012 Aug 15;125(Pt 16):3858-69. doi: 10.1242/jcs.104018. Epub 2012 May 17.
4
Adapter protein SH2B1beta binds filamin A to regulate prolactin-dependent cytoskeletal reorganization and cell motility.衔接蛋白SH2B1β与细丝蛋白A结合，以调节催乳素依赖性细胞骨架重组和细胞运动。
Mol Endocrinol. 2011 Jul;25(7):1231-43. doi: 10.1210/me.2011-0056. Epub 2011 May 12.
5
Structural and functional aspects of filamins.细丝蛋白的结构和功能方面
Biochim Biophys Acta. 2001 Apr 23;1538(2-3):99-117. doi: 10.1016/s0167-4889(01)00072-6.
6
Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site.核糖体S6激酶（RSK）在一个重要的调节位点上调节细丝蛋白A的磷酸化。
Mol Cell Biol. 2004 Apr;24(7):3025-35. doi: 10.1128/MCB.24.7.3025-3035.2004.
7
Structural and functional evaluation of C. elegans filamins FLN-1 and FLN-2.秀丽隐杆线虫肌联蛋白 FLN-1 和 FLN-2 的结构与功能评估。
PLoS One. 2011;6(7):e22428. doi: 10.1371/journal.pone.0022428. Epub 2011 Jul 25.
8
Dopamine D2 and D3 receptors are linked to the actin cytoskeleton via interaction with filamin A.多巴胺D2和D3受体通过与细丝蛋白A相互作用而与肌动蛋白细胞骨架相连。
Proc Natl Acad Sci U S A. 2001 Apr 24;98(9):5258-63. doi: 10.1073/pnas.011538198.
9
Structural basis of filamin A functions.细丝蛋白A功能的结构基础。
J Cell Biol. 2007 Dec 3;179(5):1011-25. doi: 10.1083/jcb.200707073.
10
Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.细丝蛋白A与细丝蛋白GAP相互作用的分子基础及其在与细丝蛋白A突变相关的先天性疾病中的损害。
PLoS One. 2009;4(3):e4928. doi: 10.1371/journal.pone.0004928. Epub 2009 Mar 18.
引用本文的文献
1
Filamin A in the ovary: a mediator of granulosa cell functions.卵巢中的细丝蛋白A：颗粒细胞功能的调节因子
Reprod Fertil. 2025 Jul 30. doi: 10.1530/RAF-25-0013.
2
The Life of a Kidney Podocyte.肾足细胞的生命历程。
Acta Physiol (Oxf). 2025 Aug;241(8):e70081. doi: 10.1111/apha.70081.
3
Unveiling the multifaceted role of the FLNC gene: implications for cancer diagnosis and prognosis.揭示FLNC基因的多方面作用：对癌症诊断和预后的影响。
Eur J Med Res. 2025 Jul 9;30(1):608. doi: 10.1186/s40001-025-02876-x.
4
LRRC8A/PKC/FLNA pathway activation is detrimental to colon cancer patients.LRRC8A/PKC/FLNA信号通路激活对结肠癌患者有害。
Funct Integr Genomics. 2025 Jun 27;25(1):138. doi: 10.1007/s10142-025-01650-w.
5
Effect of Mutations in the C-Terminal 22-24 Domains of Filamin C Associated with Cardio- and Myopathies on Its Interaction with Small Heat Shock Protein HspB7.与心脏和肌肉疾病相关的细丝蛋白C C末端22 - 24结构域突变对其与小分子热休克蛋白HspB7相互作用的影响。
Int J Mol Sci. 2025 Jun 9;26(12):5512. doi: 10.3390/ijms26125512.
6
Filamin A editing in myeloid cells reduces intestinal inflammation and protects from colitis.髓系细胞中细丝蛋白A的编辑可减轻肠道炎症并预防结肠炎。
J Exp Med. 2025 Sep 1;222(9). doi: 10.1084/jem.20240109. Epub 2025 Jun 5.
7
The FLNA Gene in Tumour-Educated Platelets Can Be Utilised to Identify High-Risk Populations for NSCLCs.肿瘤诱导血小板中的FLNA基因可用于识别非小细胞肺癌的高危人群。
J Cell Mol Med. 2025 Apr;29(7):e70544. doi: 10.1111/jcmm.70544.
8
Dilated cardiomyopathy: from genes and molecules to potential treatments.扩张型心肌病：从基因与分子到潜在治疗方法
Mol Cell Biochem. 2025 Mar 29. doi: 10.1007/s11010-025-05269-0.
9
Mutations in Filamin C Associated with Both Alleles Do Not Affect the Functioning of Mice Cardiac Muscles.与两个等位基因相关的细丝蛋白C突变不影响小鼠心肌的功能。
Int J Mol Sci. 2025 Feb 7;26(4):1409. doi: 10.3390/ijms26041409.
10
Proteomic and metabolomic profiling of aged pork loin chops reveals molecular phenotypes linked to pork tenderness.老年猪里脊肉的蛋白质组学和代谢组学分析揭示了与猪肉嫩度相关的分子表型。
J Anim Sci. 2024 Jan 3;102. doi: 10.1093/jas/skae355.
本文引用的文献
1
Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion.细丝蛋白 A 调节黏着斑解体，抑制乳腺癌细胞迁移和侵袭。
J Exp Med. 2010 Oct 25;207(11):2421-37. doi: 10.1084/jem.20100433. Epub 2010 Oct 11.
2
A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.一种新的 FlnA 和 Syk 相互作用调节血小板 ITAM 介导的受体信号转导和功能。
J Exp Med. 2010 Aug 30;207(9):1967-79. doi: 10.1084/jem.20100222. Epub 2010 Aug 16.
3
FLN-1/filamin is required for maintenance of actin and exit of fertilized oocytes from the spermatheca in C. elegans.FLN-1/filamin 在 C. elegans 中对于肌动蛋白的维持和受精卵从受精囊的排出是必需的。
Dev Biol. 2010 Nov 15;347(2):247-57. doi: 10.1016/j.ydbio.2010.08.005. Epub 2010 Aug 10.
4
Pro-prion binds filamin A, facilitating its interaction with integrin beta1, and contributes to melanomagenesis.原朊病毒结合细丝蛋白 A，促进其与整合素 β1 的相互作用，并有助于黑色素瘤的发生。
J Biol Chem. 2010 Sep 24;285(39):30328-39. doi: 10.1074/jbc.M110.147413. Epub 2010 Jul 21.
5
R-Ras regulates migration through an interaction with filamin A in melanoma cells.R-Ras 通过与黑色素瘤细胞中的细丝蛋白 A 相互作用调节迁移。
PLoS One. 2010 Jun 23;5(6):e11269. doi: 10.1371/journal.pone.0011269.
6
Dictyostelium amoebae and neutrophils can swim.变形虫和嗜中性粒细胞可以游动。
Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11376-80. doi: 10.1073/pnas.1006327107. Epub 2010 Jun 8.
7
Electron tomography reveals unbranched networks of actin filaments in lamellipodia.电子断层扫描揭示了片状伪足中无分支的肌动蛋白丝网络。
Nat Cell Biol. 2010 May;12(5):429-35. doi: 10.1038/ncb2044. Epub 2010 Apr 25.
8
Biochemical basis of the interaction between cystic fibrosis transmembrane conductance regulator and immunoglobulin-like repeats of filamin.囊性纤维化跨膜电导调节蛋白与细丝蛋白免疫球蛋白样重复序列相互作用的生化基础。
J Biol Chem. 2010 May 28;285(22):17166-76. doi: 10.1074/jbc.M109.080911. Epub 2010 Mar 29.
9
Cystic fibrosis transmembrane conductance regulator interacts with multiple immunoglobulin domains of filamin A.囊性纤维化跨膜电导调节蛋白与细丝蛋白 A 的多个免疫球蛋白结构域相互作用。
J Biol Chem. 2010 May 28;285(22):17156-65. doi: 10.1074/jbc.M109.080523. Epub 2010 Mar 29.
10
Novel interactors and a role for supervillin in early cytokinesis.新型相互作用蛋白及早期胞质分裂中超微丝束结合蛋白的作用
Cytoskeleton (Hoboken). 2010 Jun;67(6):346-64. doi: 10.1002/cm.20449.
Zotero 插件