Vasil'ev S A, Krylov V V, Pesnia-Prasolov S B, Zuev A A, Pavlov V N, Zhidkov I L, Fedorov D N, Khovrin V V
Khirurgiia (Mosk). 2010(10):62-8.
26 animals (13 pigs and 13 rabbits) were involved in the study. Liquid nitrogen cryodestruction experimental machine was used. The following measurements and investigation were performed: invasive temperature measurement, intraoperative ultrasound, magnetic resonance imaging and pathomorphologic assessment. An ice sphere was hypoechogenic with hyperechogenic contour by ultrasound. Postoperative MRI showed signs of local ischemic oedema in cryodestruction zone, no signs of bleeding were detected. Morphologically zones of total necrosis, oedema and minor dystrophic changes were recognized. Cryodestruction proved to be a reliable technique of cold brain necrosis.
26只动物（13头猪和13只兔子）参与了该研究。使用了液氮冷冻破坏实验机器。进行了以下测量和研究：有创温度测量、术中超声、磁共振成像和病理形态学评估。超声显示冰球呈低回声，轮廓为高回声。术后MRI显示冷冻破坏区有局部缺血性水肿迹象，未检测到出血迹象。形态学上识别出完全坏死、水肿和轻微营养不良变化区域。冷冻破坏被证明是一种可靠的脑冷坏死技术。
