为什么我们需要进行一项关于睾酮治疗对老年男性影响的试验？

Why do we need a trial on the effects of testosterone therapy in older men?

机构信息

Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Clin Pharmacol Ther. 2011 Jan;89(1):29-31. doi: 10.1038/clpt.2010.217.

DOI:10.1038/clpt.2010.217

PMID:21170069

Abstract

Decreases in levels of sex hormones occur with aging. Observational studies have found associations of low testosterone concentrations in older men with adverse symptoms; however, these associations do not prove causality. Therefore, the question arises whether to treat older men whose serum testosterone is low. In 2009, the Testosterone Trial (T Trial) was funded to examine the efficacy of therapy in 800 elderly men with low testosterone levels; potentially associated symptoms; and abnormalities in physical, sexual, or cognitive function or vitality.

摘要

随着年龄的增长，性激素水平会下降。观察性研究发现，老年男性睾丸酮浓度低与不良症状有关；然而，这些关联并不能证明因果关系。因此，问题是是否要治疗血清睾丸酮水平低的老年男性。2009 年， Testosterone Trial（T 试验）获得资助，以检查 800 名低睾丸酮水平、潜在相关症状、身体、性或认知功能或活力异常的老年男性的治疗效果。