补充细胞内钙储备。
Refilling Intracellular Calcium Stores.
作者信息
Kho Changwon, Lee Ahyoung, Jeong Dongtak, Hajjar Roger J
机构信息
Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY10029, USA.
出版信息
Drug Discov Today Dis Mech. 2010 Summer;7(2):e145-e150. doi: 10.1016/j.ddmec.2010.08.004.
Abstract
Within the cardiac cell, the movements of calcium ions are tightly regulated by a number of regulatory proteins including pumps, and channels. The sarcoplasmic reticulum (SR) is in large part responsible for orchestrating these movements for the normal functioning of the cardiomyocyte. Alterations of SR regulatory proteins in failing hearts leads to abnormal Ca(2+) homeostasis and consequently to a deficient contractile state. This review focuses on the roles of SR Ca(2+) regulators in disease states and novel strategies for therapeutic targeting of these pathways.
摘要
在心肌细胞内，钙离子的运动受到包括泵和通道在内的多种调节蛋白的严格调控。肌浆网（SR）在很大程度上负责协调这些运动，以维持心肌细胞的正常功能。衰竭心脏中SR调节蛋白的改变会导致异常的Ca(2+) 稳态，进而导致收缩功能不足。本文综述聚焦于SR Ca(2+) 调节蛋白在疾病状态下的作用以及针对这些途径的新型治疗策略。
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