低分辨率生物X射线晶体学的发展
Developments in low-resolution biological X-ray crystallography.
作者信息
Dyda Fred
机构信息
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health Bethesda, MD 20892 USA.
出版信息
F1000 Biol Rep. 2010 Nov 11;2:80. doi: 10.3410/B2-80.
Abstract
Despite the recent substantial technological developments in X-ray crystallography, solving and refining structures at low resolutions remain substantial challenges. Many macromolecular crystals, especially those of large molecules or multicomponent assemblies, diffract X-rays to resolutions that are worse than 3.5Å. This report summarizes several recent advances aiding low resolution crystallographic work.
摘要
尽管最近X射线晶体学技术取得了重大进展，但在低分辨率下解析和精修结构仍然面临巨大挑战。许多大分子晶体，尤其是那些大分子或多组分组装体的晶体，将X射线衍射到比3.5埃更差的分辨率。本报告总结了有助于低分辨率晶体学工作的几项最新进展。
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