CAS Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R & A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, P. R. China.
Electrophoresis. 2011 Jan;32(1):105-15. doi: 10.1002/elps.201000349. Epub 2010 Dec 3.
Organic-silica hybrid monolithic columns have drawn more and more attention due to the ease of preparation and good mechanical stability in recent years. Many synthetic approaches have been developed and a variety of hybrid monolithic capillary columns have been prepared. The sol-gel process is well recognized in the fabrication of hybrid monolithic columns, which can be mainly classified as one-step, acid/base two-step procedures. The new approaches such as the "one-pot" and nano-scaled inorganic-organic hybrid reagent of polyhedral oligomeric silsesquioxane used as a cross-linker have also emerged for the preparation of hybrid monolithic columns. The applications of the organic-silica hybrid monolithic capillary columns for capillary electrochromatography, micro high-performance liquid chromatography, solid-phase micro-extraction and enzymatic reactor etc. are included in this review.
近年来，由于制备简单、机械稳定性好，有机-硅杂化整体柱受到了越来越多的关注。已经开发出许多合成方法，并制备了各种杂化整体毛细管柱。溶胶-凝胶法在杂化整体柱的制备中得到了广泛的认可，主要可分为一步法、酸碱两步法。为了制备杂化整体柱，还出现了一些新方法，如多面体低聚倍半硅氧烷作为交联剂的“一锅法”和纳米级无机-有机杂化试剂。本文综述了有机-硅杂化整体毛细管柱在毛细管电色谱、微高效液相色谱、固相微萃取和酶反应器等方面的应用。
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