Pauwels R
University Hospital, Department of Respiratory Diseases, Ghent, Belgium.
Lung. 1990;168 Suppl:221-9. doi: 10.1007/BF02718136.
Hyperresponsiveness is a key abnormality in asthma and deserves recognition both in the clinical presentation of asthma and its pathogenesis. Available evidence strongly suggests that inflammatory processes are important in producing this aspect of disordered airway physiology. Pharmacologic studies have greatly increased our knowledge of mechanisms involved in hyperresponsiveness but fall short of a complete explanation of the phenomenon. It is most likely that hyperresponsiveness, as measured in the laboratory, has many different components and that any single mechanism will be an insufficient explanation.
高反应性是哮喘的关键异常表现，在哮喘的临床表现及其发病机制中均值得关注。现有证据有力地表明，炎症过程在导致这种气道生理紊乱方面起着重要作用。药理学研究极大地增加了我们对高反应性相关机制的认识，但仍不足以完全解释这一现象。很可能实验室检测到的高反应性有许多不同的组成部分，任何单一机制都不足以解释该现象。
