Yang Cui-hua, Zhang Chun-ni
PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China.
Zhonghua Nan Ke Xue. 2010 Sep;16(9):844-9.
MicroRNAs (miRNAs), with the length of about 22 nucleotides, are a growing family of small non-protein-coding RNAs that function as post-transcriptional regulators of target genes, involved in multiple processes of life and closely related with tumorigenesis. Recently, some aberrantly expressed miRNAs have been discovered in the prostate, indicating that miRNA may play a critical role in the molecular mechanism of the pathogenesis of prostate cancer. With deeper studies on human serum and plasma miRNAs, serum miRNA is promising to be a potential diagnostic biomarker for prostate cancer.
微小RNA（miRNA）长度约为22个核苷酸，是一个不断发展的小型非蛋白质编码RNA家族，作为靶基因的转录后调节因子发挥作用，参与生命的多个过程，与肿瘤发生密切相关。最近，在前列腺中发现了一些异常表达的miRNA，这表明miRNA可能在前列腺癌发病机制的分子机制中起关键作用。随着对人血清和血浆miRNA的深入研究，血清miRNA有望成为前列腺癌的潜在诊断生物标志物。
