Vaarala Markku, Perttilä Ilkka, Hellström Pekka
OYS:n kirurgian klinikka Pl 21.
Duodecim. 2010;126(21):2511-7.
Urological and gastroenterological patients may benefit from the therapeutic use of botulinum neurotoxin. Urologic indications include overactive bladder refractory to conventional treatments, painful bladder, chronic pelvic pain syndromes and problems with bladder emptying. Currently, there are no approved therapeutic indications for urologic conditions. In general, botulinum neurotoxin treatment is well tolerated and adverse events are predictable and limited to the urogenital tract, though rare severe and fatal complications have been reported.
泌尿科和肠胃科患者可能会从肉毒杆菌神经毒素的治疗应用中受益。泌尿科的适应症包括对传统治疗无效的膀胱过度活动症、膀胱疼痛、慢性盆腔疼痛综合征以及膀胱排空问题。目前,对于泌尿系统疾病尚无获批的治疗适应症。一般来说,肉毒杆菌神经毒素治疗的耐受性良好,不良事件可预测且仅限于泌尿生殖道,不过也有罕见的严重和致命并发症的报告。