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烟酸缓释剂（ER）/辛伐他汀（Simcor®）：在血脂调节中的应用指南。

Niacin extended release (ER)/simvastatin (Simcor®): a guide to its use in lipid regulation.

机构信息

Adis, a Wolters Kluwer Business, Auckland, New Zealand.

出版信息

Drugs R D. 2010;10(4):253-60. doi: 10.2165/11202560-000000000-00000.

DOI:10.2165/11202560-000000000-00000
PMID:21171671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3586144/
Abstract

Oral fixed-dose niacin extended release/simvastatin is associated with clinically relevant improvements in plasma lipid profiles, including lowering of non-high-density lipoprotein cholesterol levels, relative to simvastatin monotherapy in patients with mixed dyslipidemias who had not responded fully to simvastatin monotherapy, and is generally well tolerated.

摘要

口服固定剂量烟酸缓释/辛伐他汀与辛伐他汀单药治疗相比，可使混合性血脂异常患者的血脂谱得到临床相关改善，包括降低非高密度脂蛋白胆固醇水平，这些患者对辛伐他汀单药治疗反应不完全，且通常具有良好的耐受性。

相似文献

1
Niacin extended release (ER)/simvastatin (Simcor®): a guide to its use in lipid regulation.烟酸缓释剂（ER）/辛伐他汀（Simcor®）：在血脂调节中的应用指南。
Drugs R D. 2010;10(4):253-60. doi: 10.2165/11202560-000000000-00000.
2
Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: the OCEANS study.烟酸缓释片与辛伐他汀联合应用于血脂异常患者的长期安全性和疗效：OCEANS研究
Am J Cardiovasc Drugs. 2008;8(2):69-81. doi: 10.2165/00129784-200808020-00001.
3
Management of complex lipid abnormalities with a fixed dose combination of simvastatin and extended release niacin.使用辛伐他汀与缓释烟酸固定剂量组合治疗复杂脂质异常
Vasc Health Risk Manag. 2009;5(1):31-43. doi: 10.2147/vhrm.s3190. Epub 2009 Apr 8.
4
Targeting multiple dyslipidemias with fixed combinations--focus on extended release niacin and simvastatin.使用固定复方制剂治疗多种血脂异常——聚焦于缓释烟酸与辛伐他汀
Vasc Health Risk Manag. 2008;4(5):1001-9. doi: 10.2147/vhrm.s3460.
5
Comparison of once-daily, niacin extended-release/lovastatin with standard doses of atorvastatin and simvastatin (the ADvicor Versus Other Cholesterol-Modulating Agents Trial Evaluation [ADVOCATE]).每日一次的烟酸缓释/洛伐他汀与标准剂量阿托伐他汀和辛伐他汀的比较（ADvicor与其他胆固醇调节药物试验评估[ADVOCATE]）
Am J Cardiol. 2003 Mar 15;91(6):667-72. doi: 10.1016/s0002-9149(03)00007-9.
6
Niacin extended-release/simvastatin combination therapy produces larger favorable changes in high-density lipoprotein particles than atorvastatin monotherapy.烟酸缓释剂/辛伐他汀联合疗法比阿托伐他汀单一疗法在高密度脂蛋白颗粒方面产生更大的有利变化。
Vasc Health Risk Manag. 2012;8:39-44. doi: 10.2147/VHRM.S22601. Epub 2012 Jan 25.
7
Cost-effectiveness of extended-release niacin/laropiprant added to a stable simvastatin dose in secondary prevention patients not at cholesterol goal in Germany.在德国，对于未达到胆固醇目标的二级预防患者，在稳定剂量辛伐他汀的基础上添加烟酸/拉罗匹仑缓释片的成本效益。
Eur J Health Econ. 2012 Jun;13(3):365-74. doi: 10.1007/s10198-011-0309-z. Epub 2011 Apr 5.
8
Effects of low-dose of niacin associated to simvastatin in the treatment of mixed dyslipidemia Salgad.低剂量烟酸联合辛伐他汀治疗混合性血脂异常的效果 萨尔加德
Minerva Cardioangiol. 2010 Oct;58(5):531-42.
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Niacin extended-release therapy in phase III clinical trials is associated with relatively low rates of drug discontinuation due to flushing and treatment-related adverse events: a pooled analysis.烟酸缓释治疗在 III 期临床试验中与因潮红和治疗相关不良事件而停药的相对较低的发生率相关：一项汇总分析。
Am J Cardiovasc Drugs. 2011 Jun 1;11(3):179-87. doi: 10.2165/11592560-000000000-00000.
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Fixed-dose combination of extended-release niacin plus simvastatin for lipid disorders.缓释烟酸与辛伐他汀固定剂量复方制剂用于治疗脂质紊乱
Expert Rev Cardiovasc Ther. 2008 Nov;6(10):1303-10. doi: 10.1586/14779072.6.10.1303.

引用本文的文献

1
Quantification of Niacin and Its Metabolite Nicotinuric Acid in Human Plasma by LC-MS/MS: Application to a Clinical Trial of a Fixed Dose Combination Tablet of Niacin Extended-Release/Simvastatin (500 mg/10 mg) in Healthy Chinese Volunteers.采用液相色谱-串联质谱法对人血浆中烟酸及其代谢产物烟尿酸进行定量分析：应用于烟酸缓释片/辛伐他汀（500mg/10mg）固定剂量复方片剂在健康中国志愿者中的临床试验。
Int J Anal Chem. 2015;2015:212437. doi: 10.1155/2015/212437. Epub 2015 Aug 5.

本文引用的文献

1
Efficacy and safety of combination therapy with niacin extended-release and simvastatin versus atorvastatin in patients with dyslipidemia: The SUPREME Study.烟酸缓释剂与辛伐他汀联合治疗与阿托伐他汀治疗血脂异常患者的疗效和安全性：SUPREME 研究。
J Clin Lipidol. 2009 Apr;3(2):109-18. doi: 10.1016/j.jacl.2009.02.009. Epub 2009 Feb 11.
2
Comparison of the efficacy and safety of a combination tablet of niacin extended-release and simvastatin with simvastatin 80 mg monotherapy: the SEACOAST II (high-dose) study.烟酸缓释片与辛伐他汀 80mg 单药治疗的疗效和安全性比较：SEACOAST II（高剂量）研究。
J Clin Lipidol. 2008 Apr;2(2):79-90. doi: 10.1016/j.jacl.2008.02.004. Epub 2008 Feb 15.
3
The ARBITER 6-HALTS Trial (Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol 6-HDL and LDL Treatment Strategies in Atherosclerosis): final results and the impact of medication adherence, dose, and treatment duration.
ARBITER 6-HALTS 试验（动脉生物学用于研究降低胆固醇 6-HDL 和 LDL 治疗策略在动脉粥样硬化中的治疗效果）：最终结果以及药物依从性、剂量和治疗持续时间的影响。
J Am Coll Cardiol. 2010 Jun 15;55(24):2721-6. doi: 10.1016/j.jacc.2010.03.017.
4
Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebo-controlled, magnetic resonance imaging study.高剂量缓释烟酸对动脉粥样硬化和血管功能的影响：一项随机、安慰剂对照的磁共振成像研究。
J Am Coll Cardiol. 2009 Nov 3;54(19):1787-94. doi: 10.1016/j.jacc.2009.06.036.
5
Combined use of extended-release niacin and atorvastatin: safety and effects on lipid modification.缓释烟酸与阿托伐他汀联合使用：安全性及对血脂调节的作用
Chin Med J (Engl). 2009 Jul 20;122(14):1615-20.
6
The mechanism and mitigation of niacin-induced flushing.烟酸引起的潮红的机制与缓解。
Int J Clin Pract. 2009 Sep;63(9):1369-77. doi: 10.1111/j.1742-1241.2009.02099.x.
7
Acetylsalicylic acid reduces niacin extended-release-induced flushing in patients with dyslipidemia.乙酰水杨酸可减轻血脂异常患者中烟酸缓释制剂引起的潮红。
Am J Cardiovasc Drugs. 2009;9(2):69-79. doi: 10.1007/BF03256578.
8
Flushing ASsessment Tool (FAST): psychometric properties of a new measure assessing flushing symptoms and clinical impact of niacin therapy.潮红评估工具（FAST）：一种评估潮红症状及烟酸治疗临床影响的新测量方法的心理测量特性。
Clin Drug Investig. 2009;29(4):215-29. doi: 10.2165/00044011-200929040-00001.
9
Comparison of the safety and efficacy of a combination tablet of niacin extended release and simvastatin vs simvastatin monotherapy in patients with increased non-HDL cholesterol (from the SEACOAST I study).烟酸缓释片与辛伐他汀联合片剂和辛伐他汀单药治疗对非高密度脂蛋白胆固醇升高患者的安全性和疗效比较（来自SEACOAST I研究）
Am J Cardiol. 2008 May 15;101(10):1428-36. doi: 10.1016/j.amjcard.2008.02.092.
10
Long-term safety and efficacy of a combination of niacin extended release and simvastatin in patients with dyslipidemia: the OCEANS study.烟酸缓释片与辛伐他汀联合应用于血脂异常患者的长期安全性和疗效：OCEANS研究
Am J Cardiovasc Drugs. 2008;8(2):69-81. doi: 10.2165/00129784-200808020-00001.