醋酸阿比特龙。

Abiraterone acetate.

出版信息

Drugs R D. 2010;10(4):261-9. doi: 10.2165/11587960-000000000-00000.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3586139/

Abstract

Abiraterone acetate (CB 7630; CB7630; JNJ-212082), the 3β-acetate prodrug of abiraterone, is structurally related to ketoconazole and is being developed by Cougar Biotechnology as a hormonal therapy for advanced prostate and breast cancers. As a selective inhibitor of adrenal androgens, it is thought to be a safer product than existing second-line hormonal therapies. This review discusses the key development milestones and therapeutic trials of this drug.

摘要

醋酸阿比特龙（CB7630；CB7630；JNJ-212082）是阿比特龙的 3β-醋酸酯前药，与酮康唑结构相关，由 Cougar Biotechnology 开发用于治疗晚期前列腺癌和乳腺癌的激素疗法。作为一种选择性的肾上腺雄激素抑制剂，它被认为是比现有二线激素疗法更安全的产品。本文综述了该药物的关键开发里程碑和临床试验。