Medway School of Science, University of Greenwich, Chatham Maritime ME4 4TB, Kent, UK.
J Microencapsul. 2011;28(1):74-81. doi: 10.3109/02652048.2010.529948.
Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24 h showing negligible cell cytotoxicity up to 15 mg/mL.
采用无溶剂高压均质法（HPH）制备了负载布洛芬（IBU）的固体脂质纳米粒（SLNs）。所制备的 SLNs 由硬脂酸、三榈酸甘油酯或三硬脂酸甘油酯作为脂质基质和各种稳定剂组成。对制备的空白和 IBU 负载的 SLNs 进行了 8 个月以上的粒径稳定性考察。采用差示扫描量热法（DSC）和 X 射线衍射（XRD）对冷冻干燥 SLNs 中的 IBU 状态进行了表征。结果表明，IBU 以无定形和结晶形式存在于脂质基质中。冻干粉末显示出 IBU 溶解速率随脂质性质的增加而增加。SLNs 在 Caco-2 细胞中孵育 24 h，细胞毒性可忽略不计，最高可达 15 mg/mL。
