Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine (Omori), Toho University School of Medicine, Tokyo, Japan.
Diabetol Metab Syndr. 2010 Dec 20;2:71. doi: 10.1186/1758-5996-2-71.
To date, there have been no reports on the prevalence of adrenal masses in type 2 diabetic patients. The present study aimed to evaluate the prevalence of adrenal incidentaloma in type 2 diabetic patients in Japan.
We retrospectively evaluated the presence of adrenal masses using abdominal CT scans in 304 type 2 diabetic patients. In those with adrenal masses, we examined the hormone production capacity of the adrenal mass.
Fourteen patients (4.6%) had an adrenal mass. Hormonal analysis identified one case as having subclinical Cushing's syndrome, two with primary aldosteronism. Eleven cases had non-functioning masses.
The reported prevalence of adrenal incidentaloma in normal subjects is 0.6-4.0% in abdominal CT scan series. Our results show a relatively high prevalence of adrenal tumors in diabetic patients. On the other hand, the frequency of functional adenoma in diabetic patients is 21.4%, which is similar to that of normal subjects.
Although further studies are needed to evaluate the prevalence of adrenal tumors in diabetic patients, our data suggest that evaluation of the presence of adrenal masses may be needed in patients with type 2 diabetes mellitus.
迄今为止，尚无关于 2 型糖尿病患者肾上腺肿块患病率的报道。本研究旨在评估日本 2 型糖尿病患者肾上腺意外瘤的患病率。
我们回顾性地评估了 304 例 2 型糖尿病患者的腹部 CT 扫描中是否存在肾上腺肿块。对于有肾上腺肿块的患者，我们检查了肾上腺肿块的激素产生能力。
14 名患者（4.6%）有肾上腺肿块。激素分析发现 1 例为亚临床库欣综合征，2 例为原发性醛固酮增多症。11 例为无功能肿块。
腹部 CT 扫描系列中报告的正常人群中肾上腺意外瘤的患病率为 0.6-4.0%。我们的结果显示，糖尿病患者的肾上腺肿瘤患病率相对较高。另一方面，糖尿病患者功能性腺瘤的频率为 21.4%，与正常人群相似。
尽管需要进一步研究来评估糖尿病患者肾上腺肿瘤的患病率，但我们的数据表明，可能需要对 2 型糖尿病患者存在的肾上腺肿块进行评估。
