Department of Urology, University of California San Francisco, San Francisco, California 94143-0738, USA.
J Urol. 2011 Feb;185(2):673-80. doi: 10.1016/j.juro.2010.09.118. Epub 2010 Dec 18.
Copious studies exist regarding the use of stents in pediatric pyeloplasty. Most surgeons use either no stent, an internal (Double-J®) stent or an external transanastomotic pyeloureteral stent. We propose the first known study to compare all 3 methods using a decision tree model that incorporates success rates, complications, patient discomfort and costs.
We created a deterministic decision tree model. We conducted a literature search querying urinary diversion in pediatric pyeloplasty. We used the largest studies for base inputs and remaining studies for sensitivity analysis. Direct costs from actual patients seen at the University of California San Francisco populated cost inputs.
Total quality adjusted life-years during a 16-year period for no stents was 12.70851 with a total cost of $6,122. Total quality adjusted life-years for external stents was 12.71098 at a total cost of $5,702. Internal stents resulted in total quality adjusted life-years of 12.69983 and cost of $8,421. Thus, external stents dominated no stents and internal stents, while no stents dominated internal stents. On sensitivity analysis even decreasing complication and failure rates of internal stents to zero did not make them cost effective due to the costs associated with stent removal. In contrast, decreasing complication and pyeloplasty rates of no stents by 20% resulted in an incremental cost-effectiveness ratio of $5,475 per quality adjusted life-year gained compared to external stents.
External and no stents are superior to internal stents. Given high overall success rates of pyeloplasty regardless of stent method, perhaps more attention should be given to cost from a health policy standpoint.
大量研究已经探讨了支架在小儿肾盂成形术中的应用。大多数外科医生使用无支架、内置(双 J®)支架或外置经吻合口肾盂输尿管支架。我们提出了第一个已知的使用决策树模型比较所有 3 种方法的研究,该模型纳入了成功率、并发症、患者不适和成本。
我们创建了一个确定性决策树模型。我们进行了文献检索,查询小儿肾盂成形术中的尿流改道。我们使用最大的研究作为基础输入,其余研究进行敏感性分析。来自加利福尼亚大学旧金山分校实际患者的直接成本作为成本输入。
16 年内无支架的总质量调整生命年为 12.70851,总成本为 6122 美元。外置支架的总质量调整生命年为 12.71098,总成本为 5702 美元。内置支架的总质量调整生命年为 12.69983,成本为 8421 美元。因此,外置支架优于无支架和内置支架,而无支架优于内置支架。敏感性分析甚至将内置支架的并发症和失败率降低到零,也不会使其具有成本效益,因为支架取出相关的成本较高。相比之下,将无支架的并发症和肾盂成形术失败率降低 20%,与外置支架相比,每增加一个质量调整生命年的增量成本效益比为 5475 美元。
外置和无支架优于内置支架。鉴于肾盂成形术的总体成功率较高,无论支架方法如何,从卫生政策的角度来看,或许应该更加关注成本问题。