Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA.
Anal Chem. 2011 Feb 1;83(3):1144-7. doi: 10.1021/ac102550e. Epub 2010 Dec 21.
The coupling of a high partial pressure water vapor system to a conventional X-ray photoelectron spectroscopy instrument for use with both organic powders and single crystals is described. The modified chamber serves a dual purpose as both a treatment and sample preparation apparatus. The design utilizes the high- and cryo-temperature capabilities of the existing system to allow investigation of various states of surface water, as well as the interplay between temperature, water, and surface structure of the substrate. Sample handling and methods for compatibility testing are detailed, and data illustrating the application of the modified and integrated capabilities are summarized, detailing novel studies on the state of water on the surface of model organic pharmaceutical salts. In addition to facilitating investigation of the presence of various states of water at the surface of organic material, namely, dissociated versus molecular water, the setup allows the investigation of structural effects of the surface on the state of water.
介绍了将高分压水蒸气系统与传统的 X 射线光电子能谱仪相结合，用于有机粉末和单晶的方法。该改进后的腔室具有双重用途，既是处理装置，也是样品制备装置。该设计利用现有系统的高温和低温能力，允许研究各种表面水状态，以及温度、水和基质表面结构之间的相互作用。详细介绍了样品处理和兼容性测试方法，并总结了应用改进和集成功能的数据，这些数据详细说明了模型有机药物盐表面上水状态的新研究。除了促进对有机材料表面各种状态的水（即游离水和分子水）的存在的研究外，该装置还允许研究表面对水的状态的结构影响。
