Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biomedical Research, Graduate School of Biomedical Sciences, Hiroshima University, Japan Liver Research Project Center, Hiroshima, Japan.
J Gastroenterol Hepatol. 2011 Jan;26(1):13-8. doi: 10.1111/j.1440-1746.2010.06470.x.
Human hepatitis B virus (HBV) and hepatitis C virus (HCV) infect only chimpanzees and humans. Analysis of both viruses has long been hampered by the absence of a small animal model. The recent development of human hepatocyte chimeric mice has enabled us to carry out studies on viral replication and cellular changes induced by replication of human hepatitis viruses. Various therapeutic agents have also been tested using this model. In the present review, we summarize published studies using chimeric mice and discuss the merits and shortcomings of this model.
人类乙型肝炎病毒 (HBV) 和丙型肝炎病毒 (HCV) 仅感染黑猩猩和人类。由于缺乏小动物模型，对这两种病毒的分析一直受到阻碍。最近，人源肝细胞嵌合小鼠的发展使我们能够进行研究人类肝炎病毒复制和复制引起的细胞变化。还使用这种模型测试了各种治疗剂。在本综述中，我们总结了使用嵌合小鼠的已发表研究，并讨论了该模型的优点和缺点。
