Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea.
J Gastroenterol Hepatol. 2011 Jan;26(1):44-8. doi: 10.1111/j.1440-1746.2010.06477.x.
The adjuvant effects of probiotic-containing yogurt on second-line triple therapy for Helicobacter pylori (H. pylori) infection have not been evaluated.
A total of 337 patients with persistent H. pylori infection, after first-line triple therapy, were randomly assigned to receive either triple therapy with (yogurt group, n=151) or without (control group, n=186) Will yogurt. Triple therapy consisted of 400 mg moxifloxacin q.d., 1000 mg amoxicillin b.i.d., and 20 mg esomeprazole b.i.d. for 14 days. Will yogurt contains Lactobacillus acidophilus, Lactobacillus casei, Bifidobacterium longum, and Streptococcus thermophilus. H. pylori eradication was evaluated by the (13)C-urea breath test, histology, or the rapid urease test.
The eradication rates by intention-to-treat analysis were 66.7% and 68.9% in the control and yogurt groups, respectively (P=0.667). The eradication rates by per-protocol analysis were 78.5% and 86% in the control and the yogurt groups, respectively (P=0.110). The adverse event rates were 25.3% and 28.5% in the control group and yogurt group, respectively (P=0.508).
The addition of yogurt containing probiotics to moxifloxacin-containing second-line treatment neither improved H. pylori eradication rates nor reduced the adverse events of treatment.
含益生菌酸奶对幽门螺杆菌（H. pylori）感染二线三联疗法的辅助作用尚未得到评估。
共有 337 例持续性 H. pylori 感染患者，在一线三联疗法后，随机分为接受含（酸奶组，n=151）或不含（对照组，n=186）Will 酸奶的三线治疗。三线治疗包括每天 400 mg 莫西沙星、每天 1000 mg 阿莫西林和每天 20 mg 埃索美拉唑，共 14 天。Will 酸奶含有嗜酸乳杆菌、干酪乳杆菌、长双歧杆菌和嗜热链球菌。通过（13）C-尿素呼气试验、组织学或快速尿素酶试验评估 H. pylori 根除情况。
意向治疗分析的根除率分别为对照组和酸奶组的 66.7%和 68.9%（P=0.667）。按方案分析的根除率分别为对照组和酸奶组的 78.5%和 86%（P=0.110）。对照组和酸奶组的不良反应发生率分别为 25.3%和 28.5%（P=0.508）。
在含莫西沙星的二线治疗中添加含益生菌的酸奶既不能提高 H. pylori 的根除率，也不能降低治疗的不良反应。
