Centre for Transplant and Renal Research, Westmead Millennium Institute, University of Sydney at Westmead Hospital, Sydney, New South Wales, Australia.
Nephrology (Carlton). 2011 Jan;16(1):30-8. doi: 10.1111/j.1440-1797.2010.01383.x.
Adriamycin nephropathy (AN) is a rodent model of chronic kidney disease that has been studied extensively and has enabled a greater understanding of the processes underlying the progression of chronic proteinuric renal disease. AN is characterized by podocyte injury followed by glomerulosclerosis, tubulointerstitial inflammation and fibrosis. Genetic studies have demonstrated a number of loci that alter both risk and severity of renal injury induced by Adriamycin. Adriamycin-induced renal injury has been shown in numerous studies to be modulated by both non-immune and immune factors, and has facilitated further study of mechanisms of tubulointerstitial injury. This review will outline the pharmacological behaviour of Adriamycin, and describe in detail the model of AN, including its key structural characteristics, genetic susceptibility and pathogenesis.
阿霉素肾病（AN）是一种慢性肾病的啮齿动物模型，已经得到了广泛的研究，使人们对慢性蛋白尿性肾病进展的过程有了更深入的了解。AN 的特征是足细胞损伤，随后发生肾小球硬化、肾小管间质炎症和纤维化。遗传研究已经证实了一些改变阿霉素诱导的肾脏损伤风险和严重程度的基因座。大量研究表明，阿霉素诱导的肾损伤可被非免疫和免疫因素调节，并促进了对肾小管间质损伤机制的进一步研究。这篇综述将概述阿霉素的药理学行为，并详细描述 AN 模型，包括其关键结构特征、遗传易感性和发病机制。
