巴基斯坦单一中心成人原发性肾活检中观察到的肾脏疾病模式。

Pattern of renal diseases observed in native renal biopsies in adults in a single centre in Pakistan.

机构信息

Histopathology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan.

出版信息

Nephrology (Carlton). 2011 Jan;16(1):87-92. doi: 10.1111/j.1440-1797.2010.01410.x.

DOI:10.1111/j.1440-1797.2010.01410.x

PMID:21175983

Abstract

AIM

In the absence of a national renal biopsy registry, there is a paucity of information on the pattern of renal disease observed in native renal biopsies in adults in Pakistan.

METHODS

A retrospective review of native renal biopsies performed in adult patients was undertaken at the Sindh Institute of Urology and Transplantation (SIUT) during the period from July 1995 to December 2008. Renal biopsies were studied by light, immunofluorescence and electron microscopy. The renal biopsy diagnoses were categorized into the following groups: glomerulopathies (GN), tubulointerstitial diseases (TID), renal vascular diseases (VD), and hereditary diseases (HD).

RESULTS

A total of 1793 adult patients were included in the study. GN was the commonest diagnosis representing 83.9% of all biopsies. Primary GN (PGN) accounted for 86.9% and secondary GN (SGN) for 13%. When PGN was further analyzed, focal segmental glomerulosclerosis (FSGS) was the leading histopathological diagnosis, found in 29% of PGN, followed by membranous GN (MGN), seen in 23.5% of cases. Among SGN, lupus nephritis (44.1%) was the commonest, followed by amyloidosis (42.1%) and diabetic nephropathy (8.1%). TID comprised 11.6% of all renal biopsy diagnoses. VD and HD were less frequent, found in 3.9% and 0.4%, respectively.

CONCLUSION

The pattern of biopsied renal pathology is similar to that reported recently from other parts of the world with similar biopsy indications.

摘要

目的

由于缺乏全国性的肾活检登记，因此，对于巴基斯坦成年人的原发性肾活检中观察到的肾脏疾病模式，我们知之甚少。

方法

我们对 1995 年 7 月至 2008 年 12 月期间在信德省泌尿学和移植研究所（SIUT）进行的成人原发性肾活检进行了回顾性研究。通过光镜、免疫荧光和电子显微镜检查肾活检。将肾活检诊断分为以下几类：肾小球疾病（GN）、肾小管间质性疾病（TID）、肾血管疾病（VD）和遗传性疾病（HD）。

结果

本研究共纳入 1793 例成年患者。GN 是最常见的诊断，占所有活检的 83.9%。原发性 GN（PGN）占 86.9%，继发性 GN（SGN）占 13%。当进一步分析 PGN 时，局灶节段性肾小球硬化症（FSGS）是主要的组织病理学诊断，占 PGN 的 29%，其次是膜性肾小球肾炎（MGN），占 23.5%。在 SGN 中，狼疮性肾炎（44.1%）最为常见，其次是淀粉样变性（42.1%）和糖尿病肾病（8.1%）。TID 占所有肾活检诊断的 11.6%。VD 和 HD 的发生率较低，分别为 3.9%和 0.4%。