Wang Zhi-qiang, Xie Li-wei, Wu Hong-fang, Wang Zong-min
Department of Pathology, Yu Ying Children's Hospital, Wenzhou Medical College, Wenzhou 325000, China.
Zhonghua Er Ke Za Zhi. 2010 Oct;48(10):779-82.
To study the etiology and clinicopathological features of neonatal spontaneous gastric perforation.
The clinical data of 15 cases with neonatal gastric perforation seen from 2001 to 2009 were retrospectively analyzed. Immunohistochemical staining was adopted for all the cases.
The typical clinical manifestations of this disease were vomiting, abdominal distention and respiratory distress. Abdominal orthostatic X-ray showed free gas under diaphragm and seroperitoneum. In most of the cases the stomach perforation occurred at the greater curvature. Eight of the cases died in this group, the mortality was 53.33%. Six of the deaths occurred within 1 day after birth with symptoms. There were thinning and defect of stomach wall muscle and interstitial cells of Cajal (ICC) reduction as demonstrated by microscope.
Spontaneous neonatal gastric perforation is associated with abnormal gastric wall structure and reduction of ICC. Prognosis is closely related to the time of onset and the timely surgical operation.
探讨新生儿自发性胃穿孔的病因及临床病理特征。
回顾性分析2001年至2009年收治的15例新生儿胃穿孔的临床资料，并对所有病例进行免疫组织化学染色。
该病典型临床表现为呕吐、腹胀及呼吸窘迫。腹部立位X线片显示膈下游离气体及腹腔积液。多数病例胃穿孔发生于胃大弯处。该组8例死亡，死亡率为53.33%。其中6例于出生后1天内出现症状死亡。显微镜下可见胃壁肌层变薄、缺损，Cajal间质细胞（ICC）减少。
新生儿自发性胃穿孔与胃壁结构异常及ICC减少有关。预后与发病时间及能否及时手术密切相关。
