[N-钙黏蛋白作为人脐静脉内皮细胞对烟曲霉的黏附及内吞作用的受体]
[N-cadherin as a receptor for adhesion and endocytosis of Aspergillus fumigatus by human umbilical vein endothelial cells].
作者信息
Xu Xiao-Yong, Shi Yi, Zhang Peng-Peng, Shen Yu-Ying, Zhang Feng, Song Yong
机构信息
Department of Respiratory Medicine, the Second Military Medical University, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
出版信息
Zhonghua Jie He He Hu Xi Za Zhi. 2010 Oct;33(10):734-7.
OBJECTIVE
To study the receptor for adhesion and endocytosis of Aspergillus fumigatus hyphae by human umbilical vein endothelial cells (HUVEC).
METHODS
Aspergillus fumigatus hyphae were incubated with the total protein of HUVEC for investigating the binding of N-cadherin and the fungus. After the model of adhesion and endocytosis of Aspergillus fumigatus by HUVEC was established, the capacity of adhesion and endocytosis was evaluated with the presence of the antibody to N-cadherin.
RESULTS
N-cadherin sticked to the surface of Aspergillus fumigatus. Adhesion and endocytosis were inhibited with the presence of the antibody to N-cadherin.
CONCLUSION
N-cadherin is a receptor for adhesion and endocytosis of Aspergillus fumigatus by HUVEC.
目的
研究人脐静脉内皮细胞（HUVEC）对烟曲霉菌丝的黏附及内吞受体。
方法
将烟曲霉菌丝与人脐静脉内皮细胞的总蛋白共同孵育，以研究N-钙黏蛋白与真菌的结合情况。在建立人脐静脉内皮细胞对烟曲霉的黏附及内吞模型后，通过加入N-钙黏蛋白抗体来评估黏附及内吞能力。
结果
N-钙黏蛋白黏附于烟曲霉表面。加入N-钙黏蛋白抗体后，黏附及内吞作用受到抑制。
结论
N-钙黏蛋白是人脐静脉内皮细胞对烟曲霉的黏附及内吞受体。
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