Zhu Xin, Ying Li-sha, Xu Shen-hua, Zhu Chi-hong, Xie Jin-bo
Zhejiang Cancer Research Institute, Zhejiang Cancer Hospital, Hangzhou 310022, China.
Zhonghua Bing Li Xue Za Zhi. 2010 Oct;39(10):666-70.
To study the clinicopathologic and prognostic significance of serum levels of six cytokines (IFN-γ, TNF-α, IL-10, IL-5, IL-4, IL-2) in patients with advanced serous ovarian cancer prior to surgery.
The serum levels of six cytokines were detected in 51 patients with advanced serous ovarian cancer and 46 healthy controls, using cytometric bead arrays.
The serum levels of IFN-γ (20.68±11.45), IL-2 (4.54±1.18), IL-4 (5.66±2.25), IL-5 (2.72±0.86) µg/L and IL-10 (5.93±7.92) µg/L were higher (P<0.01, P<0.05) and the serum level of TNF-α (7.53±8.47) was lower (P<0.01) in patients with advanced serous ovarian cancer than those in the healthy controls. The IFN-γ/IL-4 ratio (3.93±2.34) of the patients was lower than that of the controls (P<0.01). Kaplan-Meier analysis revealed that patient's age (P=0.016), menopausal status (P=0.001) and serum IL-10 level (P=0.010) correlated significantly with patient's survival. Cox regression analysis showed that serum IL-2 (P=0.045) and IL-10 levels (P=0.007) were the independent prognostic factors.
Patients with advanced serous ovarian cancer have Th1/Th2 imbalance and immune function disturbance. The age of patients and menopausal status are important prognostic factors. IL-2 and IL-10 level are also independent predictors of survival.
研究晚期浆液性卵巢癌患者术前血清中六种细胞因子（IFN-γ、TNF-α、IL-10、IL-5、IL-4、IL-2）的临床病理特征及预后意义。
采用细胞计数珠阵列法检测51例晚期浆液性卵巢癌患者和46例健康对照者血清中六种细胞因子的水平。
晚期浆液性卵巢癌患者血清中IFN-γ（20.68±11.45）、IL-2（4.54±1.18）、IL-4（5.66±2.25）、IL-5（2.72±0.86）μg/L和IL-10（5.93±7.92）μg/L水平高于健康对照者（P<0.01，P<0.05），而TNF-α（7.53±8.47）水平低于健康对照者（P<0.01）。患者的IFN-γ/IL-4比值（3.93±2.34）低于对照组（P<0.01）。Kaplan-Meier分析显示，患者年龄（P=0.016）、绝经状态（P=0.001）和血清IL-10水平（P=0.010）与患者生存率显著相关。Cox回归分析表明，血清IL-2（P=0.045）和IL-10水平（P=0.007）是独立的预后因素。
晚期浆液性卵巢癌患者存在Th1/Th2失衡及免疫功能紊乱。患者年龄和绝经状态是重要的预后因素。IL-2和IL-10水平也是生存的独立预测指标。
