Wu Xiao-Guang, Tang Zhe, Fang Xiang-Hua, Guan Shao-Chen, Liu Hong-Jun, Diao Li-Jun, Sun Fei
Department of Epidemical and Social Medicine, Xuan-wu Hospital of Capital Medical University, Beijing Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2010 Nov;31(11):1245-9.
To study the incidence of dementia and its risk factors among the elderly living in the community of Beijing.
A sample of 2788 elderly residents from Beijing were investigated regarding the incidence of dementia which was diagnosed using two-stage method in 1997. In the first stage, questionnaire was filled, including MMSE checked up. In the second stage, all the elderly who had lower MMSE score and some with normal MMSE score were examined by neurologists. The clinical diagnosis of dementia was set up by two neurologists according to the criteria of DSM-III-R and NINCDS-ADRDA. The same sample was followed up on 2000 and 2004 by the same way, with the overall time for following-up as 7.25 years.
171 dementias cases were diagnosed among the 2788 elderly in 1997. At the end of the survey, another 180 new cases developed. The average weighted incidence was 0.84/100 person year, adjusted by age (it's same followed), with 0.64/100 person year in males and 1.01/100 person years in females. The incidence of vascular dementia was 0.35/100 person years, with male as 0.39/100 person year and female as 0.32/100 person years. The incidence of dementia was increasing with age, but decreasing with time of education by Multinomial Logistic Regression Analysis. Old age and illiterate appeared to be the risk factors for dementia. People with stroke history and elevated systolic blood pressure were risk factors for vascular dementia.
The incidence of dementia in the elderly in Beijing was higher than in other areas of China. Old age and illiterate were risk factors for dementia. Being male, illiterate, with stroke history and elevated systolic blood pressure were risk factors for vascular dementia.
研究北京市社区老年人痴呆症的发病率及其危险因素。
对2788名北京老年居民进行抽样调查，采用两阶段法于1997年诊断痴呆症发病率。第一阶段，填写问卷，包括简易精神状态检查表（MMSE）检查。第二阶段，所有MMSE得分较低以及部分MMSE得分正常的老年人由神经科医生进行检查。两名神经科医生根据《精神疾病诊断与统计手册》第三版修订本（DSM-III-R）和美国国立神经病学、语言障碍和卒中研究所 - 阿尔茨海默病及相关疾病协会（NINCDS-ADRDA）的标准进行痴呆症的临床诊断。以同样方式于2000年和2004年对同一样本进行随访，随访总时长为7.25年。
1997年在2788名老年人中诊断出171例痴呆症病例。调查结束时，又出现了180例新病例。平均加权发病率为0.84/100人年，按年龄调整（后续相同），男性为0.64/100人年，女性为1.01/100人年。血管性痴呆的发病率为0.35/100人年，男性为0.39/100人年，女性为0.32/100人年。通过多项逻辑回归分析，痴呆症发病率随年龄增长而增加，但随受教育时间减少。高龄和文盲似乎是痴呆症的危险因素。有中风病史和收缩压升高的人是血管性痴呆的危险因素。
北京老年人痴呆症的发病率高于中国其他地区。高龄和文盲是痴呆症的危险因素。男性、文盲、有中风病史和收缩压升高是血管性痴呆的危险因素。
