Zheng Jin, Ye Ping, Wang Fan, Xiao Wen-Kai, Wu Hong-Mei
Second Department of Cardiology, Southern Building Clinic Division, PLA General Hospital, Beijing 100853, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2010 Nov;31(11):1250-4.
Microalbuminuria (MAU) is generally defined as an early effective index of cardiovascular disease and renal disease. Our study aims to investigate the prevalence of MAU and its related factors among people living in Beijing.
In a cross-sectional study, 2080 subjects (810 men and 1270 women) are recruited, with age distribution as 50.87 ± 13.10 years (mean ± standard deviation). Urine albumin-creatinine ratio (ACR) is used to screen for microalbuminuria. All the data is analyzed with multivariate logistic regression method to explore the related factors for MAU.
The overall prevalence of MAU in general population of Beijing is 17.50%, with male as 15.43% and female as 18.82% (P < 0.05). Results from the multivariate logistic regression analysis reveal that the independent risk factors of MAU in men are age (OR = 1.02), blood pressure (OR = 1.02), serum creatinine (OR = 1.04), while age (OR = 1.04), systolic blood pressure (OR = 1.02), serum creatinine (OR = 1.08), body mass index (OR = 1.07), total cholesterol (OR = 2.05) in women. The protective factor of MAU in women is HDL-C (OR = 0.44).
Our findings indicate that the prevalence of MAU in Beijing area is higher than those in other areas in China or abroad. The prevalence in females is higher than that in males (P < 0.05). There is a gender difference in the related factors of MAU.
微量白蛋白尿(MAU)通常被定义为心血管疾病和肾脏疾病的早期有效指标。我们的研究旨在调查北京地区人群中MAU的患病率及其相关因素。
在一项横断面研究中,招募了2080名受试者(810名男性和1270名女性),年龄分布为50.87±13.10岁(均值±标准差)。采用尿白蛋白肌酐比值(ACR)筛查微量白蛋白尿。所有数据采用多因素逻辑回归方法进行分析,以探讨MAU的相关因素。
北京地区普通人群中MAU的总体患病率为17.50%,男性为15.43%,女性为18.82%(P<0.05)。多因素逻辑回归分析结果显示,男性MAU的独立危险因素为年龄(OR=1.02)、血压(OR=1.02)、血清肌酐(OR=1.04),而女性为年龄(OR=1.04)、收缩压(OR=1.02)、血清肌酐(OR=1.08)、体重指数(OR=1.07)、总胆固醇(OR=2.05)。女性MAU的保护因素为高密度脂蛋白胆固醇(HDL-C,OR=0.44)。
我们的研究结果表明,北京地区MAU的患病率高于中国其他地区或国外。女性患病率高于男性(P<0.05)。MAU的相关因素存在性别差异。