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中国一般人群中微量白蛋白尿的患病率及其与代谢综合征各组分的关系。

The prevalence of microalbuminuria and its relationships with the components of metabolic syndrome in the general population of China.

机构信息

Department of Laboratory Medicine, The First Affiliated Hospital of Medical College, Zhejiang University, 79 QingChun Road, Hangzhou, 310003, Zhejiang Province, People's Republic of China.

出版信息

Clin Chim Acta. 2010 May 2;411(9-10):705-9. doi: 10.1016/j.cca.2010.01.038. Epub 2010 Feb 4.

DOI:10.1016/j.cca.2010.01.038
PMID:20138167
Abstract

BACKGROUND

Few studies have examined the relationships between the prevalence of microalbuminuria and the metabolic risk factors in the general population of China. We performed a population based study to investigate the prevalence of microalbuminuria and its relationships with the components of the metabolic syndrome in Hangzhou, China.

METHODS

The subjects of this cross-sectional study were the individuals from 19 to 87 y. The metabolic syndrome was defined based on the criteria of the Chinese Diabetes Society (CDS). Microalbuminuria was defined as a urine albumin-creatinine ratio of 30 to 300 mg/g.

RESULTS

A total of 2985 subjects (average age of 44 y) were analyzed. Among them, the prevalence of the metabolic syndrome and microalbuminuria was 12.6% and 8.8%, respectively. Microalbuminuria prevalence rate was significantly higher in the population >60 y than <60 y. The prevalence of MAU in the group with metabolic abnormalities was significantly higher than the control group, and the prevalence rate of MAU in the metabolic syndrome group reached up to 20.3%. There was a significantly positive correlation between the prevalence of microalbuminuria and the corresponding components of the metabolic syndrome (P<0.001).

CONCLUSIONS

Microalbuminuria was highly prevalent in the middle-aged and elderly Chinese population in the city of Hangzhou. There is an increasing likelihood of having microalbuminuria if subjects have the metabolic syndrome. Early screening strategies for prevention and treatment of MAU are strongly suggested, especially in the population >60 y and the ones with metabolic abnormalities.

摘要

背景

很少有研究调查过中国普通人群中微量白蛋白尿的流行率与代谢危险因素之间的关系。我们进行了一项基于人群的研究,以调查中国杭州微量白蛋白尿的流行率及其与代谢综合征成分之间的关系。

方法

本横断面研究的对象是 19 至 87 岁的个体。代谢综合征的定义基于中国糖尿病协会(CDS)的标准。微量白蛋白尿定义为尿白蛋白与肌酐比值为 30 至 300mg/g。

结果

共分析了 2985 名受试者(平均年龄为 44 岁)。其中,代谢综合征和微量白蛋白尿的患病率分别为 12.6%和 8.8%。>60 岁人群的微量白蛋白尿患病率明显高于<60 岁人群。代谢异常组的 MAU 患病率明显高于对照组,代谢综合征组的 MAU 患病率高达 20.3%。微量白蛋白尿的患病率与代谢综合征的相应成分呈显著正相关(P<0.001)。

结论

杭州市中老年人群中微量白蛋白尿的患病率较高。如果患者患有代谢综合征,则发生微量白蛋白尿的可能性会增加。强烈建议对 MAU 进行早期筛查策略,特别是在>60 岁人群和代谢异常人群中。

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