Program in Nutritional Metabolism and Neuroendocrine Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, LON 211, Boston, Massachusetts 02114, USA.
J Clin Endocrinol Metab. 2011 Mar;96(3):817-23. doi: 10.1210/jc.2010-2264. Epub 2010 Dec 22.
Previous studies have suggested a relationship between GH and mitochondrial function. However, little is known about the relationship of specific GH indices and in vivo measures of mitochondrial function in humans.
The objective of this study was to determine the association between GH, IGF-I, and phosphocreatine (PCr) recovery, a measure of mitochondrial function, in otherwise healthy adults.
Thirty-seven healthy men and women were studied at a single university medical center. Subjects underwent GH stimulation testing with GH releasing hormone-arginine and measurement of IGF-I. Mitochondrial function was determined by PCr recovery after submaximal exercise by (31)Phosphorous magnetic resonance spectroscopy. Subjects underwent assessment of lean and fat mass with use of dual energy X-ray absorptiometry.
There were no differences in PCr recovery between men and women (men 20.7±1.5 vs. women 24.8±1.4 mM/min; P > 0.05). IGF-I (r = 0.33; P = 0.04) was associated with PCr recovery in all subjects. Among men, IGF-I (r = 0.69; P = 0.003), peak stimulated GH (r = 0.52; P = 0.04), and GH area under the curve (AUC) (r = 0.53; P = 0.04) were significantly associated with PCr recovery. However, neither IGF-I, peak stimulated GH, nor GH AUC (all P > 0.05) were associated with PCr recovery in women. After adjusting for age, race, and physical activity, IGF-I remained significantly associated with PCr recovery (β = 0.10; P = 0.02) among men.
IGF-I, peak stimulated GH, and GH AUC are associated with skeletal muscle PCr recovery in men.
先前的研究表明，GH 与线粒体功能之间存在关联。然而，人们对人类特定 GH 指数与体内线粒体功能的关系知之甚少。
本研究旨在确定 GH、IGF-I 和磷酸肌酸（PCr）恢复之间的关系，PCr 恢复是一种衡量线粒体功能的指标，在其他健康成年人中。
37 名健康的男性和女性在一家大学医学中心接受了 GH 刺激测试，使用 GH 释放激素-精氨酸和 IGF-I 测量。通过（31）磷磁共振波谱法测量亚最大运动后的 PCr 恢复来确定线粒体功能。使用双能 X 射线吸收仪评估瘦体重和脂肪量。
男性和女性之间的 PCr 恢复没有差异（男性 20.7±1.5 与女性 24.8±1.4 mM/min；P>0.05）。IGF-I（r=0.33；P=0.04）与所有受试者的 PCr 恢复相关。在男性中，IGF-I（r=0.69；P=0.003）、峰值刺激 GH（r=0.52；P=0.04）和 GH 曲线下面积（AUC）（r=0.53；P=0.04）与 PCr 恢复显著相关。然而，IGF-I、峰值刺激 GH 和 GH AUC 在女性中均与 PCr 恢复无关（均 P>0.05）。在调整年龄、种族和体力活动后，IGF-I 与男性的 PCr 恢复仍然显著相关（β=0.10；P=0.02）。
IGF-I、峰值刺激 GH 和 GH AUC 与男性骨骼肌 PCr 恢复相关。
