Sugiyama Y, Yoshida A, Takao H, Kunieda K, Miya K, Azuma S, Tanemura H, Furuta T, Saji S
2nd Dept. of Surgery, Gifu University, School of Medicine.
Gan To Kagaku Ryoho. 1990 Aug;17(8 Pt 2):1592-5.
In order to improve the prognosis, intraoperative intraperitoneal administration of both mitomycin C and OK-432 was performed for the peritoneal dissemination of gastric cancer. Some 74 of 469 patients of gastric cancer, who underwent surgical treatment over the last 7 years in our department, had peritoneal dissemination and 24 of them were treated with the drugs described above. However, there was no significant difference between treated group and controlled untreated group. No severe side effects were noted except for moderate pyrexia. It is still too early to determine the effect of this treatment because of both the short duration of follow-up and the small number of analyzed cases. In the future, we are planning to apply this treatment to selected cases, for which a histological diagnosis will be made intraoperatively by use of irrigation cytology and/or stamp biopsy.
为改善预后，对胃癌腹膜播散患者术中进行了丝裂霉素C和OK-432的腹腔内给药。在过去7年中，我科接受手术治疗的469例胃癌患者中，约74例有腹膜播散，其中24例接受了上述药物治疗。然而，治疗组与未治疗的对照组之间无显著差异。除中度发热外，未观察到严重副作用。由于随访时间短且分析病例数少，目前确定该治疗方法的效果还为时过早。未来，我们计划将这种治疗方法应用于选定的病例，术中通过冲洗细胞学检查和/或印片活检进行组织学诊断。
