人类癌症酪氨酸磷酸组。
Inside the human cancer tyrosine phosphatome.
机构信息
Goodman Cancer Research Centre, Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
出版信息
Nat Rev Cancer. 2011 Jan;11(1):35-49. doi: 10.1038/nrc2980.
Members of the protein tyrosine phosphatase (Ptp) family dephosphorylate target proteins and counter the activities of protein tyrosine kinases that are involved in cellular phosphorylation and signalling. As such, certain PTPs might be tumour suppressors. Indeed, PTPs play an important part in the inhibition or control of growth, but accumulating evidence indicates that some PTPs may exert oncogenic functions. Recent large-scale genetic analyses of various human tumours have highlighted the relevance of PTPs either as putative tumour suppressors or as candidate oncoproteins. Progress in understanding the regulation and function of PTPs has provided insights into which PTPs might be potential therapeutic targets in human cancer.
蛋白酪氨酸磷酸酶（Ptp）家族的成员可使靶蛋白去磷酸化，拮抗参与细胞磷酸化和信号转导的蛋白酪氨酸激酶的活性。因此，某些 Ptp 可能是肿瘤抑制因子。事实上，Ptp 在抑制或控制生长中起着重要作用，但越来越多的证据表明，某些 Ptp 可能发挥致癌功能。最近对各种人类肿瘤的大规模遗传分析强调了 Ptp 作为潜在肿瘤抑制因子或候选癌蛋白的相关性。对 Ptp 调节和功能的深入了解为确定哪些 Ptp 可能成为人类癌症的潜在治疗靶点提供了线索。
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