在药物化学课程中运用主动学习练习来教授药物-受体相互作用。
Active-learning exercises to teach drug-receptor interactions in a medicinal chemistry course.
机构信息
College of Pharmacy, University of Louisiana at Monroe, LA 71201, USA.
出版信息
Am J Pharm Educ. 2010 Oct 11;74(8):147. doi: 10.5688/aj7408147.
OBJECTIVE
To incorporate structural biology, enzyme kinetics, and visualization of protein structures in a medicinal chemistry course to teach fundamental concepts of drug design and principles of drug action.
DESIGN
Pedagogy for active learning was incorporated via hands-on experience with visualization software for drug-receptor interactions and concurrent laboratory sessions. Learning methods included use of clicker technology, in-class assignments, and analogies.
ASSESSMENT
Quizzes and tests that included multiple-choice and open-ended items based on Bloom's taxonomy were used to assess learning. Student feedback, classroom exercises, and tests were used to assess teaching methods and effectiveness in meeting learning outcomes.
CONCLUSION
The addition of active-learning activities increased students' understanding of fundamental medicinal chemistry concepts such as ionization state of molecules, enzyme kinetics, and the significance of protein structure in drug design.
目的
在药物化学课程中融入结构生物学、酶动力学和蛋白质结构可视化内容，以教授药物设计的基本概念和药物作用原理。
设计
通过药物-受体相互作用的可视化软件的实际操作以及同时进行的实验室课程，将主动学习的教学法融入课程。学习方法包括使用点击器技术、课堂作业和类比。
评估
采用多项选择题和基于布鲁姆分类法的开放式问题的测验来评估学习情况。学生反馈、课堂练习和测验用于评估教学方法和实现学习成果的效果。
结论
增加主动学习活动提高了学生对基本药物化学概念的理解，例如分子的电离状态、酶动力学以及蛋白质结构在药物设计中的重要性。
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