Marchand William R, Bennett Pamela J, Dilda Dott Ssa Valentina
All from the George E. Wahlen VAMC and the University of Utah, Salt Lake City, Utah.
Psychiatry (Edgmont). 2005 Apr;2(4):26-33.
Most of the literature on bipolar disorder has focused on abnormalities of neurotransmitters rather than brain circuits. The few discussions of circuits have primarily focused on the limbic system. Evidence is accumulating, however, that basal ganglia-thalamic-cortical reentrant circuits play a major role in the affective, motor and cognitive symptoms of a number of neuropsychiatric conditions including bipolar disorder. In this paper, the authors argue that there is compelling direct and indirect evidence of frontal-subcortical circuit abnormalities in patients with bipolar affective disorder.
大多数关于双相情感障碍的文献都聚焦于神经递质异常而非脑回路。对脑回路的少数讨论主要集中在边缘系统。然而，越来越多的证据表明，基底神经节-丘脑-皮质折返回路在包括双相情感障碍在内的多种神经精神疾病的情感、运动和认知症状中起主要作用。在本文中，作者认为有令人信服的直接和间接证据表明双相情感障碍患者存在额叶-皮质下回路异常。
