[川芎嗪对肝脏缺血再灌注损伤时脂质过氧化的影响]
[Effects of ligustrazin on lipid peroxidation during hepatic ischemia reperfusion injury].
作者信息
Xu Zheng-Jie, Wang Wan-Tie, Li Dong, Lin Li-Na
机构信息
Department of Pathophysiology, Wenzhou Medical College, Wenzhou 325027, China.
出版信息
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2002 May;18(2):173-5.
AIM
To explore the role of ligustrazin on dynamic changes of lipid peroxidation in hepatic ischemia/reperfusion injury (HIRI) and its mechanism.
METHODS
The HIRI model was used. Twenty rabbits were randomly divided into control group (n = 10) and ligustrazin group (n = 10). The xanthine oxidase (XO) activity, superoxide dismutase (SOD) activity,malondialdehyde (MDA) content and glutamic pyruvic transaminase (GPT) activity in plasma were observed before ischemia and at ischemia 25 min, reperfusion 25 min, reperfusion 60 min and reperfusion 120 min.
RESULTS
The XO activity, SOD activity, MDA content and GPT activity of ligustrazin group, as compared with control group, showed significant differences (P < 0.05 or P < 0.01) at total time points of reperfusion.
CONCLUSION
Ligustrazin has notable anti-lipid peroxidation effect on HIRI, which is due to its inhibiting the generation of oxygen free radicals and its strengthening scavenging of oxygen free radicals.
目的
探讨川芎嗪对肝缺血/再灌注损伤（HIRI）中脂质过氧化动态变化的作用及其机制。
方法
采用HIRI模型。将20只家兔随机分为对照组（n = 10）和川芎嗪组（n = 10）。观察缺血前、缺血25分钟、再灌注25分钟、再灌注60分钟和再灌注120分钟时血浆中黄嘌呤氧化酶（XO）活性、超氧化物歧化酶（SOD）活性、丙二醛（MDA）含量和谷丙转氨酶（GPT）活性。
结果
川芎嗪组的XO活性、SOD活性、MDA含量和GPT活性与对照组相比，在再灌注各时间点均有显著差异（P < 0.05或P < 0.01）。
结论
川芎嗪对HIRI具有显著的抗脂质过氧化作用，这是由于其抑制氧自由基的产生并增强对氧自由基的清除。
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