Blackmore M, Thompson S, Turner G A
Department of Clinical Biochemistry, Medical School, University of Newcastle upon Tyne, U.K.
Clin Exp Metastasis. 1990 Sep-Oct;8(5):449-60. doi: 10.1007/BF00058155.
Interferon treatment increases the ability of tumour cells to colonize the lungs. Although it has been suggested that this effect can be explained by increases in the expression of MHC molecules the precise mechanism is still uncertain. The growth in the lungs of a low (F1) and a high colonizing variant (BL6) of the B16 mouse melanoma have been studied after in vitro treatment with interferon. Interferon-gamma, but not interferon-alpha/beta, increased the number of lung colonies formed after intravenous injection, but not after subcutaneous administration. Treatment also increased the sizes of the lung colonies formed and the number of radiolabelled cells retained by the lungs. However, no clear relationship was observed between the number of colonies formed and the concentration of interferon used. The effect of interferon on F1 was greater than on BL6, but the overall number of colonies formed was very similar. These results suggest that interferon increases the adhesiveness of these cell lines in a fairly non-specific manner, that seems unlikely to involve MHC molecules. As a results of this and other studies the importance of interferon in the process of tumour spread seems very questionable.
干扰素治疗会增强肿瘤细胞在肺部定植的能力。尽管有人认为这种效应可以用主要组织相容性复合体（MHC）分子表达的增加来解释，但确切机制仍不确定。在用干扰素进行体外处理后，对B16小鼠黑色素瘤的低定植变体（F1）和高定植变体（BL6）在肺部的生长情况进行了研究。γ干扰素而非α/β干扰素增加了静脉注射后形成的肺集落数量，但皮下给药后未增加。治疗还增加了形成的肺集落大小以及肺部保留的放射性标记细胞数量。然而，观察到形成的集落数量与所用干扰素浓度之间没有明显关系。干扰素对F1的作用大于对BL6的作用，但形成的集落总数非常相似。这些结果表明，干扰素以一种相当非特异性的方式增加了这些细胞系的黏附性，这似乎不太可能涉及MHC分子。基于这项研究和其他研究结果，干扰素在肿瘤扩散过程中的重要性似乎非常值得怀疑。
